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MedKoo Cat#: 526942 | Name: Ro 244736

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 24-4736 is a platelet activating factor inhibitor potentially for the treatment of asthma. Ro-24-4736 protects the rat kidney from ischemic injury.

Chemical Structure

Ro 244736
Ro 244736
CAS#125030-71-9

Theoretical Analysis

MedKoo Cat#: 526942

Name: Ro 244736

CAS#: 125030-71-9

Chemical Formula: C31H20ClN5OS

Exact Mass: 545.1077

Molecular Weight: 546.05

Elemental Analysis: C, 68.19; H, 3.69; Cl, 6.49; N, 12.83; O, 2.93; S, 5.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ro 24-4736; Ro24-4736; Ro-24-4736; Ro 244736; Ro244736; Ro-244736.
IUPAC/Chemical Name
5-(3-(4-(2-Chlorophenyl)-9-methyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin-2-yl)-2-propynyl)phenanthridin-6(5H)-one
InChi Key
MPMZSZMDCRPSRF-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H20ClN5OS/c1-19-34-35-28-18-33-29(24-13-4-6-14-26(24)32)25-17-20(39-31(25)37(19)28)9-8-16-36-27-15-7-5-11-22(27)21-10-2-3-12-23(21)30(36)38/h2-7,10-15,17H,16,18H2,1H3
SMILES Code
O=C1N(CC#CC(S2)=CC3=C2N4C(CN=C3C5=CC=CC=C5Cl)=NN=C4C)C6=CC=CC=C6C7=C1C=CC=C7
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 546.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jackson JR, Bolognese B, Mangar CA, Hubbard WC, Marshall LA, Winkler JD. The role of platelet activating factor and other lipid mediators in inflammatory angiogenesis. Biochim Biophys Acta. 1998 May 20;1392(1):145-52. PubMed PMID: 9593866. 2: Negro Alvarez JM, Miralles López JC, Ortiz Martínez JL, Abellán Alemán A, Rubio del Barrio R. Platelet-activating factor antagonists. Allergol Immunopathol (Madr). 1997 Sep-Oct;25(5):249-58. Review. PubMed PMID: 9395010. 3: Kelly KJ, Tolkoff-Rubin NE, Rubin RH, Williams WW Jr, Meehan SM, Meschter CL, Christenson JG, Bonventre JV. An oral platelet-activating factor antagonist, Ro-24-4736, protects the rat kidney from ischemic injury. Am J Physiol. 1996 Nov;271(5 Pt 2):F1061-7. PubMed PMID: 8946001. 4: Zellweger R, Ayala A, Schmand JF, Morrison MH, Chaudry IH. PAF-antagonist administration after hemorrhage-resuscitation prevents splenocyte immunodepression. J Surg Res. 1995 Sep;59(3):366-70. PubMed PMID: 7643595. 5: Elder CA, Modi MW. Interspecies scaling of a thienodiazepine platelet-activating factor receptor antagonist. Drug Metab Dispos. 1995 Jul;23(7):776-8. PubMed PMID: 7587967. 6: Wasserman MA, Welton AF, Renzetti LM. Synergism exhibited by LTD4 and PAF receptor antagonists in decreasing antigen-induced airway microvascular leakage. Adv Prostaglandin Thromboxane Leukot Res. 1995;23:271-3. PubMed PMID: 7732851. 7: Welton AF, O'Donnell M, Renzetti L, Simko B, Tocker J, Cashin C, Newbold P, Wasserman MA. Studies of the combination of Ro 24-5913, a peptidoleukotriene antagonist, and Ro 24-4736, a PAF antagonist, in guinea pig and rat models of lung inflammation. Ann N Y Acad Sci. 1994 Nov 15;744:274-88. PubMed PMID: 7825850. 8: Wright DT, Adler KB, Akley NJ, Dailey LA, Friedman M. Ozone stimulates release of platelet activating factor and activates phospholipases in guinea pig tracheal epithelial cells in primary culture. Toxicol Appl Pharmacol. 1994 Jul;127(1):27-36. PubMed PMID: 8048050. 9: Thompson WA, Coyle S, Van Zee K, Oldenburg H, Trousdale R, Rogy M, Felsen D, Moldawer L, Lowry SF. The metabolic effects of platelet-activating factor antagonism in endotoxemic man. Arch Surg. 1994 Jan;129(1):72-9. PubMed PMID: 8279943. 10: Anastasi EM, Williams TH, Sasso GJ, Chang D, Liberato DJ, Loh AC. Disposition and metabolism of Ro 24-4736 in the rat. Life Sci. 1994;54(26):PL483-90. PubMed PMID: 8208055. 11: Thomas TK, Chesonis RS, Schmolze D, Symington J, Harbison ML, Walser A, Will PC. Differential antagonism of platelet activating factor-induced neutrophilia and gastric hemorrhage in the rat. Agents Actions. 1993;39 Spec No:C195-7. PubMed PMID: 8273566. 12: Crowley HJ, Yaremko B, Selig WM, Janero DR, Burghardt C, Welton AF, O'Donnell M. Pharmacology of a potent platelet-activating factor antagonist: Ro 24-4736. J Pharmacol Exp Ther. 1991 Oct;259(1):78-85. PubMed PMID: 1656030. 13: O'Donnell M. Effects of Ro 24-4736 in antagonizing the platelet and bronchoconstrictor responses to PAF. Ann N Y Acad Sci. 1991;629:416-8. PubMed PMID: 1659287.

View History

BD-7162

BD-7162