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MedKoo Cat#: 526158 | Name: Ro 16-8714

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 16-8714 is a beta-adrenoreceptor agonist with thermogenic and antihyperglycemic properties.

Chemical Structure

Ro 16-8714
Ro 16-8714
CAS#90505-66-1

Theoretical Analysis

MedKoo Cat#: 526158

Name: Ro 16-8714

CAS#: 90505-66-1

Chemical Formula: C27H32N2O3

Exact Mass: 432.2413

Molecular Weight: 432.56

Elemental Analysis: C, 74.97; H, 7.46; N, 6.48; O, 11.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ro 16-8714; Ro16-8714; Ro-16-8714.
IUPAC/Chemical Name
4-(3-(Bis(beta-hydroxyphenethyl)amino)butyl)benzamide
InChi Key
OPPQEWZOPDBGAS-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H32N2O3/c1-20(12-13-21-14-16-24(17-15-21)27(28)32)29(18-25(30)22-8-4-2-5-9-22)19-26(31)23-10-6-3-7-11-23/h2-11,14-17,20,25-26,30-31H,12-13,18-19H2,1H3,(H2,28,32)
SMILES Code
O=C(N)C1=CC=C(CCC(N(CC(O)C2=CC=CC=C2)CC(O)C3=CC=CC=C3)C)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 432.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Revelli JP, Muzzin P, Giacobino JP. Modulation in vivo of beta-adrenergic-receptor subtypes in rat brown adipose tissue by the thermogenic agonist Ro 16-8714. Biochem J. 1992 Sep 15;286 ( Pt 3):743-6. PubMed PMID: 1358062; PubMed Central PMCID: PMC1132966. 2: Ferré P, Pénicaud L, Hitier Y, Meier M, Girard J. Hypoglycemic effects of a beta-agonist, Ro 16-8714, in streptozotocin-diabetic rats: decreased hepatic glucose production and increased glucose utilization in oxidative muscles. Metabolism. 1992 Feb;41(2):180-3. PubMed PMID: 1346545. 3: Muzzin P, Revelli JP, Ricquier D, Meier MK, Assimacopoulos-Jeannet F, Giacobino JP. The novel thermogenic beta-adrenergic agonist Ro 16-8714 increases the interscapular brown-fat beta-receptor-adenylate cyclase and the uncoupling-protein mRNA level in obese (fa/fa) Zucker rats. Biochem J. 1989 Aug 1;261(3):721-4. PubMed PMID: 2572217; PubMed Central PMCID: PMC1138890. 4: Henny C, Bückert A, Schutz Y, Jéquier E, Felber JP. Comparison of thermogenic activity induced by the new sympathomimetic Ro 16-8714 between normal and obese subjects. Int J Obes. 1988;12(3):227-36. PubMed PMID: 2899062. 5: Henny C, Schutz Y, Buckert A, Meylan M, Jequier E, Felber JP. Thermogenic effect of the new beta-adrenoreceptor agonist Ro 16-8714 in healthy male volunteers. Int J Obes. 1987;11(5):473-83. PubMed PMID: 2892807.