ME-3221 | CAS#139958-16-0 | AT1 antagonist

MedKoo Cat#: 526935 | Name: ME-3221

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ME-3221 is an angiotensin type 1 receptor antagonist potentially for the treatment of hypertension. ME3221 prevents hypertensive complications in aged stroke-prone spontaneously hypertensive rats. n rats and marmosets, ME3221 antagonized angiotensin II-induced pressor responses, but did not affect bradykinin-induced depressor responses. ME3221 lowered the blood pressure in renal hypertensive rats and spontaneously hypertensive rats (SHR), and its ED25 value was 3 times that of losartan.

Chemical Structure

ME-3221

CAS#139958-16-0

Theoretical Analysis

MedKoo Cat#: 526935

Name: ME-3221

CAS#: 139958-16-0

Chemical Formula: C22H21N5O2

Exact Mass: 387.1695

Molecular Weight: 387.44

Elemental Analysis: C, 68.20; H, 5.46; N, 18.08; O, 8.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ME-3221; ME3221; ME 3221.

IUPAC/Chemical Name

3-Methoxy-2,6-dimethyl-4-(2'-(1H-tetrazol-5-yl) biphenyl-4-ylmethoxy)pyridine

InChi Key

FTDRSCZZEUAAIP-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H21N5O2/c1-14-12-20(21(28-3)15(2)23-14)29-13-16-8-10-17(11-9-16)18-6-4-5-7-19(18)22-24-26-27-25-22/h4-12H,13H2,1-3H3,(H,24,25,26,27)

SMILES Code

CC1=CC(OCC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)=C(OC)C(C)=N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 387.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kawano K, Fujishima K, Nagura J, Yasuda S, Shinki, Hachisu M, Konno F. Nonpeptide angiotensin II receptor antagonist recognizes inter-species differences in angiotensin AT1 receptors. Eur J Pharmacol. 1998 Sep 11;357(1):33-9. PubMed PMID: 9788771. 2: Nagura J, Hui C, Yamamoto M, Yasuda S, Abe M, Hachisu M, Konno F. ME3221, a surmountable angiotensin AT1-receptor antagonist, prevents hypertensive complications in aged stroke-prone spontaneously hypertensive rats. Jpn J Pharmacol. 1996 May;71(1):39-49. PubMed PMID: 8791170. 3: Nagura J, Yamamoto M, Hui C, Yasuda S, Hachisu M, Konno F. Protective effects of ME3221 on hypertensive complications and lifespan in salt-loaded stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 1996 Mar;23(3):229-35. PubMed PMID: 8934613. 4: Nagura J, Yasuda S, Fujishima K, Yamamoto M, Hui C, Kawano K, Katano K, Ogino H, Hachisu M, Konno F. Pharmacological profile of ME3221, a novel angiotensin II receptor antagonist. Eur J Pharmacol. 1995 Feb 14;274(1-3):201-11. PubMed PMID: 7768273. 5: Nagura J, Hui C, Yamamoto M, Yasuda S, Abe M, Hachisu M, Konno F. Effect of chronic treatment with ME3221 on blood pressure and mortality in aged stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S363-5. PubMed PMID: 9072429.