MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 526151 | Name: Ro 15-0216

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 15-0216 is a nitroimidazole compound active in vitro against human and animal pathogenic African trypanosomes.

Chemical Structure

Ro 15-0216
Ro 15-0216
CAS#87544-68-1

Theoretical Analysis

MedKoo Cat#: 526151

Name: Ro 15-0216

CAS#: 87544-68-1

Chemical Formula: C15H19N5O4

Exact Mass: 333.1437

Molecular Weight: 333.35

Elemental Analysis: C, 54.05; H, 5.75; N, 21.01; O, 19.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Ro 15-0216; Ro15-0216; Ro-15-0216.
IUPAC/Chemical Name
Acetamide, 2-(dimethylamino)-N-(4-((1-methyl-2-nitro-1H-imidazol-5-yl)methoxy)phenyl)-
InChi Key
VBSQNHBYSYNMIG-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H19N5O4/c1-18(2)9-14(21)17-11-4-6-13(7-5-11)24-10-12-8-16-15(19(12)3)20(22)23/h4-8H,9-10H2,1-3H3,(H,17,21)
SMILES Code
O=C(NC1=CC=C(OCC2=CN=C([N+]([O-])=O)N2C)C=C1)CN(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 333.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dumas M, Bouteille B. Treatment of human African trypanosomiasis. Bull World Health Organ. 2000;78(12):1474. PubMed PMID: 11196500; PubMed Central PMCID: PMC2560654. 2: Bouteille B, Chauviere G. [Use of megazol for the treatment of trypanosomiasis]. Med Trop (Mars). 1999;59(4):321-30. Review. French. PubMed PMID: 10816740. 3: Bouteille B, Millet P, Enanga B, Mezui Me J, Keita M, Jauberteau MO, Georges A, Dumas M. [Human African trypanosomiasis, contributions of experimental models]. Bull Soc Pathol Exot. 1998;91(2):127-32. Review. French. PubMed PMID: 9642464. 4: Zweygarth E, Moloo SK, Kaminsky R. Trypanosoma simiae: in vitro studies on drug susceptibility. Acta Trop. 1993 Sep;54(3-4):301-8. PubMed PMID: 7902667. 5: Sørensen BS, Sinding J, Andersen AH, Alsner J, Jensen PB, Westergaard O. Mode of action of topoisomerase II-targeting agents at a specific DNA sequence. Uncoupling the DNA binding, cleavage and religation events. J Mol Biol. 1992 Dec 5;228(3):778-86. PubMed PMID: 1335085. 6: Sørensen BS, Fukata H, Jensen PS, Andersen AH, Christiansen K, Fukasawa H, Westergaard O. Drug Stimulated DNA Cleavage Mediated by Cauliflower Topoisomerase II. Plant Physiol. 1991 Feb;95(2):659-62. PubMed PMID: 16668035; PubMed Central PMCID: PMC1077584. 7: Zweygarth E, Kaminsky R, Sayer PD, van Nieuwenhove S. Synergistic activity of 5-substituted 2-nitroimidazoles (Ro 15-0216 and benznidazole) and DL-alpha-difluoromethylornithine on Trypanosoma brucei brucei. Ann Soc Belg Med Trop. 1990 Dec;70(4):269-79. PubMed PMID: 2291692. 8: Sørensen BS, Jensen PS, Andersen AH, Christiansen K, Alsner J, Thomsen B, Westergaard O. Stimulation of topoisomerase II mediated DNA cleavage at specific sequence elements by the 2-nitroimidazole Ro 15-0216. Biochemistry. 1990 Oct 16;29(41):9507-15. PubMed PMID: 2176847. 9: Thomsen B, Bendixen C, Lund K, Andersen AH, Sørensen BS, Westergaard O. Characterization of the interaction between topoisomerase II and DNA by transcriptional footprinting. J Mol Biol. 1990 Sep 20;215(2):237-44. PubMed PMID: 2170662. 10: Kaminsky R, Zweygarth E. Feeder layer-free in vitro assay for screening antitrypanosomal compounds against Trypanosoma brucei brucei and T. b. evansi. Antimicrob Agents Chemother. 1989 Jun;33(6):881-5. PubMed PMID: 2764539; PubMed Central PMCID: PMC284250. 11: Zweygarth E, Röttcher D. Efficacy of experimental trypanocidal compounds against a multiple drug-resistant Trypanosoma brucei brucei stock in mice. Parasitol Res. 1989;75(3):178-82. PubMed PMID: 2710771. 12: Borowy NK, Nelson RT, Hirumi H, Brun R, Waithaka HK, Schwartz D, Polak A. Ro 15-0216: a nitroimidazole compound active in vitro against human and animal pathogenic African trypanosomes. Ann Trop Med Parasitol. 1988 Feb;82(1):13-9. PubMed PMID: 3401068. 13: Bouteille B, Darde ML, Pestre-Alexandre M, Dumas M, Breton JC, Nicolas JA, Catanzano G, Munoz M. [Treatment of experimental trypanosomiasis of sheep caused by Trypanosoma brucei brucei: efficacy of Ro 15-0216 (a 2-nitroimidazole derivative)]. Bull Soc Pathol Exot Filiales. 1988;81(3 Pt 2):616-22. French. PubMed PMID: 3197255. 14: Richard-Lenoble D, Kombila MY, Felix H. [Efficacy of Ro 15-0216 against human strains of Trypanosoma gambiense maintained in rodents. A preliminary study]. Bull Soc Pathol Exot Filiales. 1988;81(3 Pt 2):609-15. French. PubMed PMID: 3197254. 15: Bouteille B, Darde ML, Pestre-Alexandre M. [Action of drugs tested in an acellular medium and in mice infected with Trypanosoma brucei brucei]. Bull Soc Pathol Exot Filiales. 1988;81(3 Pt 2):533-42. French. PubMed PMID: 3143489. 16: Zweygarth E, Röttcher D. The treatment of Trypanosoma (Nannomonas) simiae in pigs with diminazene aceturate in combination with a 5-substituted 2-nitroimidazole compound (Ro 15-0216). Trop Med Parasitol. 1987 Sep;38(3):175-6. PubMed PMID: 3432952. 17: Zweygarth E, Röttcher D. Trypanocidal activity of a 5-substituted 2-nitroimidazole compound (Ro 15-0216) in mice. Trop Med Parasitol. 1987 Sep;38(3):171-4. PubMed PMID: 3432951.