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MedKoo Cat#: 526928 | Name: FK-739 free acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FK-739 is an angiotensin type 1 receptor antagonist potentially for the treatment of hypertension. FK 739 inhibited the specific binding of [125I]-angiotensin II to rat aortic smooth muscle cell membrane with an IC50 value of 8.6 nM, but did not displace the specific binding of [125I]-angiotensin II to bovine cerebellum membrane. FK 739 might be a safe and useful agent for the treatment of hypertension in clinical trials.

Chemical Structure

FK-739 free acid
FK-739 free acid
CAS#133052-30-9

Theoretical Analysis

MedKoo Cat#: 526928

Name: FK-739 free acid

CAS#: 133052-30-9

Chemical Formula: C24H23N7

Exact Mass: 409.2015

Molecular Weight: 409.50

Elemental Analysis: C, 70.39; H, 5.66; N, 23.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
FK-739; FK 739; FK739; FK-739 free acid.
IUPAC/Chemical Name
3-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-3H-imidazo[4,5-b]pyridine
InChi Key
YILJWHUIUCRKEU-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H23N7/c1-2-3-10-22-26-21-9-6-15-25-24(21)31(22)16-17-11-13-18(14-12-17)19-7-4-5-8-20(19)23-27-29-30-28-23/h4-9,11-15H,2-3,10,16H2,1H3,(H,27,28,29,30)
SMILES Code
CCCCC1=NC2=CC=CN=C2N1CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# 133052-30-9 (FK-739 free) 136042-19-8 (FK-739 potassium salt)

Preparing Stock Solutions

The following data is based on the product molecular weight 409.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kubo M, Umemoto S, Fujii K, Itoh S, Tanaka M, Kawahara S, Matsuzaki M. Effects of angiotensin II type 1 receptor antagonist on smooth muscle cell phenotype in intramyocardial arteries from spontaneously hypertensive rats. Hypertens Res. 2004 Sep;27(9):685-93. PubMed PMID: 15750263. 2: Yonezawa T, Umemoto S, Fujii A, Katayama K, Matsuzaki M. Comparative effects of type 1 angiotensin II-receptor blockade with angiotensin-converting-enzyme inhibitor on left ventricular distensibility and collagen metabolism in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1996 Jan;27(1):119-24. PubMed PMID: 8656644. 3: Itazaki K, Hara M, Itoh N, Fujimoto M. A long-term receptor stimulation is requisite for angiotensin II-dependent DNA synthesis in vascular smooth muscle cells from spontaneously hypertensive rats. Eur J Pharmacol. 1995 Nov 30;291(3):417-25. PubMed PMID: 8719428. 4: Bauer JH, Reams GP. The angiotensin II type 1 receptor antagonists. A new class of antihypertensive drugs. Arch Intern Med. 1995 Jul 10;155(13):1361-8. Review. PubMed PMID: 7794084. 5: Hara M, Kiyama R, Nakajima S, Kawabata T, Kawakami M, Ohtani K, Itazaki K, Fujishita T, Fujimoto M. Kinetic studies on the interaction of nonlabeled antagonists with the angiotensin II receptor. Eur J Pharmacol. 1995 Apr 28;289(2):267-73. PubMed PMID: 7621900. 6: Hamada K, Nakajima Y, Nirei H, Nakajima C, Nagashima A, Sogabe K, Notsu Y, Ono T. The pharmacological characterization of FK 739, a new angiotensin II-receptor antagonist. Jpn J Pharmacol. 1993 Nov;63(3):335-43. PubMed PMID: 8107326.