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MedKoo Cat#: 328029 | Name: Milfasartan

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Milfasartan, also known as LR-B-081; LRB-081, is is a potent, selective and orally active antagonist of All at the AT1-receptor subtype, which markedly lowers the blood-pressure in conscious renal and spontaneously hypertensive rats.

Chemical Structure

Milfasartan
Milfasartan
CAS#148564-47-0

Theoretical Analysis

MedKoo Cat#: 328029

Name: Milfasartan

CAS#: 148564-47-0

Chemical Formula: C30H30N6O3S

Exact Mass: 554.2100

Molecular Weight: 554.67

Elemental Analysis: C, 64.96; H, 5.45; N, 15.15; O, 8.65; S, 5.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Milfasartan; LR-B-081; LR-B081; LR-B 081; LRB-081; LRB 081; LRB081.
IUPAC/Chemical Name
Methyl 2-((4-butyl-2-methyl-6-oxo-5-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-1(6H)-pyrimidinyl)methyl)-3-thiophenecarboxylate
InChi Key
QVFVAKQHELFATN-UHFFFAOYSA-N
InChi Code
InChI=1S/C30H30N6O3S/c1-4-5-10-26-25(29(37)36(19(2)31-26)18-27-24(15-16-40-27)30(38)39-3)17-20-11-13-21(14-12-20)22-8-6-7-9-23(22)28-32-34-35-33-28/h6-9,11-16H,4-5,10,17-18H2,1-3H3,(H,32,33,34,35)
SMILES Code
O=C(C1=C(CN(C(C)=NC(CCCC)=C2CC3=CC=C(C=C3)C4=CC=CC=C4C5=NN=NN5)C2=O)SC=C1)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 554.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Soave R, Barzaghi M, Destro R. Progress in the understanding of drug-receptor interactions, part 2: experimental and theoretical electrostatic moments and interaction energies of an angiotensin II receptor antagonist (C30H30N6(O)3S). Chemistry. 2007;13(24):6942-56. PubMed PMID: 17539033. 2: Destro R, Soave R, Barzaghi M, Lo Presti L. Progress in the understanding of drug-receptor interactions, Part 1: experimental charge-density study of an angiotensin II receptor antagonist (C30H30N6O3S) at T = 17 K. Chemistry. 2005 Aug 5;11(16):4621-34. PubMed PMID: 15915518. 3: Noël B, Del Re G, Capone P, Brunner HR, Nussberger J. Clinical and hormonal effects of the new angiotensin II receptor antagonist LRB081. J Cardiovasc Pharmacol. 1996 Aug;28(2):252-8. PubMed PMID: 8856481. 4: Polidori C, Ciccocioppo R, Pompei P, Cirillo R, Massi M. Functional evidence for the ability of angiotensin AT1 receptor antagonists to cross the blood-brain barrier in rats. Eur J Pharmacol. 1996 Jul 4;307(3):259-67. PubMed PMID: 8836613. 5: Salimbeni A, Canevotti R, Paleari F, Poma D, Caliari S, Fici F, Cirillo R, Renzetti AR, Subissi A, Belvisi L, et al. N-3-substituted pyrimidinones as potent, orally active, AT1 selective angiotensin II receptor antagonists. J Med Chem. 1995 Nov 24;38(24):4806-20. PubMed PMID: 7490730. 6: Renzetti AR, Criscuoli M, Salimbeni A, Subissi A. Molecular pharmacology of LR-B/081, a new non-peptide angiotensin AT1 receptor antagonist. Eur J Pharmacol. 1995 Jul 18;290(2):151-6. PubMed PMID: 8575530. 7: Catalioto RM, Porchia R, Renzetti AR, Criscuoli M, Subissi A, Giachetti A. Angiotensin II-induced responses in vascular smooth muscle cells: inhibition by non-peptide receptor antagonists. Eur J Pharmacol. 1995 Jul 14;280(3):285-92. PubMed PMID: 8566096. 8: Polidori C, Ciccocioppo R, Pompei P, Cirillo R, Massi M. The selective angiotensin AT1 receptor antagonist LR-B/081 potently inhibits drinking induced by central injection of angiotensin II in rats. Eur J Pharmacol. 1995 Apr 24;277(2-3):223-8. PubMed PMID: 7493612. 9: Cirillo R, Renzetti AR, Cucchi P, Guelfi M, Salimbeni A, Caliari S, Castellucci A, Evangelista S, Subissi A, Giachetti A. Pharmacology of LR-B/081, a new highly potent, selective and orally active, nonpeptide angiotensin II AT1 receptor antagonist. Br J Pharmacol. 1995 Mar;114(6):1117-24. PubMed PMID: 7620700; PubMed Central PMCID: PMC1510339.

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