Ro 12-7310 | CAS#65316-65-6

MedKoo Cat#: 526144 | Name: Ro 12-7310

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 12-7310 is a synthetic retinoid as an inhibitor of arachidonic acid release.

Chemical Structure

Ro 12-7310

CAS#65316-65-6

Theoretical Analysis

MedKoo Cat#: 526144

Name: Ro 12-7310

CAS#: 65316-65-6

Chemical Formula: C20H24O3

Exact Mass: 312.1725

Molecular Weight: 312.41

Elemental Analysis: C, 76.89; H, 7.74; O, 15.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Ro 12-7310; Ro 127310; Ro-12-7310.

IUPAC/Chemical Name

9-(4-Hydroxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid

InChi Key

CAAFTBWHFUPDGX-OFCLTBKTSA-N

InChi Code

InChI=1S/C20H24O3/c1-13(7-6-8-14(2)11-20(22)23)9-10-18-15(3)12-19(21)17(5)16(18)4/h6-12,21H,1-5H3,(H,22,23)/b8-6+,10-9+,13-7+,14-11+

SMILES Code

O=C(O)/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)C=C(O)C(C)=C1C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 312.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chaudhuri BN, Kleywegt GJ, Broutin-L'Hermite I, Bergfors T, Senn H, Le Motte P, Partouche O, Jones TA. Structures of cellular retinoic acid binding proteins I and II in complex with synthetic retinoids. Acta Crystallogr D Biol Crystallogr. 1999 Nov;55(Pt 11):1850-7. PubMed PMID: 10531482. 2: Wyss R, Bucheli F, Hartenbach R. Determination of 13-cis-3-hydroxyretinoic acid, all-trans-3-hydroxyretinoic acid and their 4-oxo metabolites in human and animal plasma by high-performance liquid chromatography with automated column switching and UV detection. J Pharm Biomed Anal. 1998 Dec;18(4-5):761-76. PubMed PMID: 9919979. 3: elAttar TM, Lin HS. In vitro inhibition of prostaglandin biosynthesis in squamous cell carcinoma by retinoids. Eicosanoids. 1990;3(2):95-8. PubMed PMID: 2144980. 4: Fiedler-Nagy C, Wittreich BH, Georgiadis A, Hope WC, Welton AF, Coffey JW. Comparative study of natural and synthetic retinoids as inhibitors of arachidonic acid release and metabolism in rat peritoneal macrophages. Dermatologica. 1987;175 Suppl 1:81-92. PubMed PMID: 2826266. 5: Stadler R, Müller R, Detmar M, Orfanos CE. Retinoids and keratinocyte differentiation in vitro. Dermatologica. 1987;175 Suppl 1:45-55. PubMed PMID: 2446936.