Ro 09-1428 | CAS#134452-47-4

MedKoo Cat#: 526139 | Name: Ro 09-1428

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 09-1428 is a parenteral cephalosporin with high antipseudomonal activity.

Chemical Structure

Ro 09-1428

CAS#134452-47-4

Theoretical Analysis

MedKoo Cat#: 526139

Name: Ro 09-1428

CAS#: 134452-47-4

Chemical Formula: C31H31N11O10S3

Exact Mass: 813.1417

Molecular Weight: 813.84

Elemental Analysis: C, 45.75; H, 3.84; N, 18.93; O, 19.66; S, 11.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

Ro 09-1428; Ro 091428; Ro-09-1428.

IUPAC/Chemical Name

7-(2-(2-Amino-4-thiazolyl)-2-((1-(3-(3,4-dihydroxybenzoyl)carbazoyl)-1-methylethoxy)imino)acetamido)-3-(((2-(hydroxymethyl)-5-methyl(1,2,4)triazolo(1,5-a)pyrimidin-7-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid

InChi Key

CCOFMFVZORWSAE-KPRPFPDJSA-N

InChi Code

InChI=1S/C31H31N11O10S3/c1-12-6-19(42-30(33-12)35-18(8-43)39-42)53-9-14-10-54-26-21(25(48)41(26)22(14)27(49)50)36-24(47)20(15-11-55-29(32)34-15)40-52-31(2,3)28(51)38-37-23(46)13-4-5-16(44)17(45)7-13/h4-7,11,21,26,43-45H,8-10H2,1-3H3,(H2,32,34)(H,36,47)(H,37,46)(H,38,51)(H,49,50)/b40-20+

SMILES Code

O=C(C(N12)=C(CSC3=CC(C)=NC4=NC(CO)=NN34)CSC2C(NC(/C(C5=CSC(N)=N5)=N/OC(C)(C(NNC(C6=CC=C(O)C(O)=C6)=O)=O)C)=O)C1=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 813.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Felici A, Perilli M, Franceschini N, Rossolini GM, Galleni M, Frere JM, Oratore A, Amicosante G. Sensitivity of Aeromonas hydrophila carbapenemase to delta3-cephems: comparative study with other metallo-beta-lactamases. Antimicrob Agents Chemother. 1997 Apr;41(4):866-8. PubMed PMID: 9087509; PubMed Central PMCID: PMC163814. 2: Qadri SM, Ayub A, Ueno Y, Saldin H. Comparative in vitro activity of Ro 09-1428, a novel cephalosporin with a catechol moiety. Clin Ther. 1992 Jul-Aug;14(4):562-9. PubMed PMID: 1525790. 3: Chin NX, Gu JW, Fang W, Neu HC. In vitro activity of Ro 09-1428 compared to other cephalosporins. Eur J Clin Microbiol Infect Dis. 1991 Aug;10(8):669-75. PubMed PMID: 1748124. 4: Arisawa M, Sekine Y, Shimizu S, Takano H, Angehrn P, Then RL. In vitro and in vivo evaluation of Ro 09-1428, a new parenteral cephalosporin with high antipseudomonal activity. Antimicrob Agents Chemother. 1991 Apr;35(4):653-9. PubMed PMID: 1906261; PubMed Central PMCID: PMC245074.