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MedKoo Cat#: 526912 | Name: TN-871 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TN-871 is a calcium and potassium channel antagonist potentially for the treatment of cerebrovascular. TN-871 modulates transmitter release from preganglionic nerve terminals without changing the postsynaptic sensitivity of the ganglion cells to ACh.

Chemical Structure

TN-871 HCl
CAS#11676-78-9 (HCl)

Theoretical Analysis

MedKoo Cat#: 526912

Name: TN-871 HCl

CAS#: 11676-78-9 (HCl)

Chemical Formula: C19H28Cl2N2O2

Exact Mass: 314.1994

Molecular Weight: 387.35

Elemental Analysis: C, 58.92; H, 7.29; Cl, 18.30; N, 7.23; O, 8.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
TN-871; TN 871; TN871; TN-871 dihydrochloride.
IUPAC/Chemical Name
1-(6-butyl-5H-indeno[5,6-d][1,3]dioxol-5-yl)-4-methylpiperazine dihydrochloride
InChi Key
InChi Code
SMILES Code
CN1CCN(C2C(CCCC)=CC3=C2C=C4C(OCO4)=C3)CC1.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
More Info
Related CAS# 118848-33-2 (TN-871) 111676-78-9 TN-871 dihyrochloride)

Preparing Stock Solutions

The following data is based on the product molecular weight 387.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Katayama Y, Morita K, Hirai K. Concentration-dependent actions of a new indene derivative, TN-871, in the enteric nervous system. Eur J Pharmacol. 1998 Jan 26;342(2-3):167-75. PubMed PMID: 9548382. 2: Shen YL, Hirai K, Katayama Y. Effects of an indene-derivative, TN-871, on synaptic transmission in a sympathetic ganglion: presynaptic actions on neurotransmitter release. Bull Tokyo Med Dent Univ. 1995 Mar;42(1):19-29. PubMed PMID: 7895315.