FPL-62129 is a calcium channel antagonist for the treatment of hypertension and myocardia ischemia. FPL-62129 reduced blood pressure without altering heart rate. FPL 62129 showed marked activity at the sinus node and to a lesser extent at the atrioventricular node. Unlike nifedipine, FPL 62129 demonstrates vasodilator and direct decelerator properties over the same dose range, which accounts for its ability to lower blood pressure without causing reflex tachycardia in this model.
MedKoo Cat#: 526910
Name: FPL-62129
CAS#: 95445-79-7
Chemical Formula: C20H19ClF5NO4
Exact Mass: 467.0923
Molecular Weight: 467.82
Elemental Analysis: C, 51.35; H, 4.09; Cl, 7.58; F, 20.31; N, 2.99; O, 13.68
The following data is based on the product molecular weight 467.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
