S-312d | S-312-d | CAS#120056-57-7 | calcium channel antagonist

MedKoo Cat#: 526904 | Name: S-312-d

Description:

WARNING: This product is for research use only, not for human or veterinary use.

S-312d, also known as S-312-d; is a calcium channel antagonist. S-312-d can offer marked neuronal protective effects against ischemic injury. S-312-d appears to be a good candidate for protection against ischemic ARF. These findings indicate that S-312-d may be clinically useful against renal ischemia.

Chemical Structure

S-312-d

CAS#120056-57-7

Theoretical Analysis

MedKoo Cat#: 526904

Name: S-312-d

CAS#: 120056-57-7

Chemical Formula: C20H22N2O4S

Exact Mass: 386.1300

Molecular Weight: 386.47

Elemental Analysis: C, 62.16; H, 5.74; N, 7.25; O, 16.56; S, 8.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

S-312d; S312d; S 312d; S-312-d; S312-d; S 312-d.

IUPAC/Chemical Name

methyl (S)-3-isobutyl-6-methyl-4-(3-nitrophenyl)-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate

InChi Key

UTLPUICHKZBRCI-KRWDZBQOSA-N

InChi Code

InChI=1S/C20H22N2O4S/c1-11(2)8-14-10-27-19-18(14)17(16(12(3)21-19)20(23)26-4)13-6-5-7-15(9-13)22(24)25/h5-7,9-11,17,21H,8H2,1-4H3/t17-/m0/s1

SMILES Code

O=C(C1=C(C)NC2=C(C(CC(C)C)=CS2)[C@H]1C3=CC=CC([N+]([O-])=O)=C3)OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 386.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Antiepileptic effects of single and repeated oral administrations of S-312-d, a novel calcium channel antagonist, on tonic convulsions in spontaneously epileptic rats. J Pharmacol Sci. 2004 Jul;95(3):355-62. PubMed PMID: 15272212. 5: Yagami T, Ueda K, Sakaeda T, Itoh N, Sakaguchi G, Okamura N, Hori Y, Fujimoto M. Protective effects of a selective L-type voltage-sensitive calcium channel blocker, S-312-d, on neuronal cell death. Biochem Pharmacol. 2004 Mar 15;67(6):1153-65. PubMed PMID: 15006551. 6: Tanaka H, Mizojiri K. Drug-protein binding and blood-brain barrier permeability. J Pharmacol Exp Ther. 1999 Mar;288(3):912-8. PubMed PMID: 10027826. 7: Takamatsu H, Kondo K, Ikeda Y, Umemura K. Neuroprotective effects depend on the model of focal ischemia following middle cerebral artery occlusion. Eur J Pharmacol. 1998 Dec 4;362(2-3):137-42. PubMed PMID: 9874163. 8: Eigyo M, Shiomi T, Inoue Y, Sakaguchi I, Ishibashi C, Murata S, Koyabu K, Matsushita A, Adachi I, Ueda M. Pharmacological studies on a new dihydrothienopyridine calcium antagonist, S-312-d. 5th communication: anticonvulsant effects in mice. Jpn J Pharmacol. 1994 Jun;65(2):175-7. PubMed PMID: 7967231. 9: Yasui M, Kawasaki K. Vulnerability of CA1 neurons in SHRSP hippocampal slices to ischemia, and its protection by Ca2+ channel blockers. Brain Res. 1994 Apr 11;642(1-2):146-52. PubMed PMID: 8032875. 10: Ueda M, Masui M, Kawakami M, Matsunaga K, Gemba T, Ninomiya M, Nakano A, Torii M, Adachi I, Ito H. Pharmacological studies on a new dihydrothienopyridine calcium antagonist. 4th communication: prophylactic and therapeutic effects of S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2, 3- b]pyridine-5-carboxylate in stroke-prone spontaneously hypertensive rats. Arzneimittelforschung. 1993 Dec;43(12):1291-303. PubMed PMID: 8141816. 11: Ueda M, Matsumura S, Masui M, Matsuura E, Kawakami M, Fujitomo H, Umeda T, Kagawa H, Hirohata S, Shima K, et al. Pharmacological studies on a new dihydrothienopyridine calcium antagonist. 3rd communication: antihypertensive effects of S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2, 3-b] pyridine-5-carboxylate in hypertensive rats and dogs. Arzneimittelforschung. 1993 Dec;43(12):1282-90. PubMed PMID: 8141815. 12: Nakajima M, Adachi I, Ueda M. Pharmacological studies on a new Dihydrothienopyridine calcium antagonist. 2nd communication: effects of S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4- (3-nitrophenyl)thieno[2,3-b]pyridine-5-carboxylate on the 1,4-dihydropyridine binding sites in the brain and on isolated arteries in the Cynomolgus monkey. Arzneimittelforschung. 1993 Dec;43(12):1276-82. PubMed PMID: 8141814. 13: Ueda M, Matsumura S, Masui M, Matsuura E, Uno O, Kawakami M, Ninomiya M, Adachi I. Pharmacological studies on a new dihydrothienopyridine calcium antagonist. 1st communication: comparative studies on the cardiovascular effects of methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2,3- b]pyridine-5-carboxylate and its two enantiomers in experimental animals. Arzneimittelforschung. 1993 Dec;43(12):1270-5. PubMed PMID: 8141813. 14: Jizomoto H, Kanaoka E, Sugita K, Hirano K. Gelatin-acacia microcapsules for trapping micro oil droplets containing lipophilic drugs and ready disintegration in the gastrointestinal tract. Pharm Res. 1993 Aug;10(8):1115-22. PubMed PMID: 8415395. 15: Gemba T, Ninomiya M, Matsunaga K, Ueda M. Effects of a novel calcium antagonist, S-(+)-methyl-4,7-dihydro-3-isobutyl-6- methyl-4-(3-nitrophenyl)thieno[2,3-b]pyridine-5-carboxylate (S-312-d), on ischemic amino acid release and neuronal injury in stroke-prone spontaneously hypertensive rats. J Pharmacol Exp Ther. 1993 Apr;265(1):463-7. PubMed PMID: 8474028. 16: Fujitomo H, Nishino I, Ueno K, Umeda T. Determination of the enantiomers of a new 1,4-dihydropyridine calcium antagonist in dog plasma by achiral/chiral coupled high-performance liquid chromatography with electrochemical detection. J Pharm Sci. 1993 Mar;82(3):319-22. Erratum in: J Pharm Sci 1993 Dec;82(12):1300. PubMed PMID: 8450429. 17: Dessy C, Salomone S, Morel N, Godfraind T. Activity of dihydrothienopyridine S312 enantiomers on L-type Ca2+ channels in isolated rat aorta and cerebral microvessels. Eur J Pharmacol. 1993 Feb 16;231(3):435-42. PubMed PMID: 8449235. 18: Nakano H, McCormick DB. Stereospecificity of the metal.ATP complex in flavokinase from rat small intestine. J Biol Chem. 1991 Nov 25;266(33):22125-8. PubMed PMID: 1657990. 19: Mihara S, Fujimoto M. Effect of S-312, a new calcium channel blocker, on the 1,4-dihydropyridine binding sites in porcine basilar blood vessels and rat aortic smooth muscle cells. Jpn J Pharmacol. 1991 Jul;56(3):249-59. PubMed PMID: 1832726. 20: Shimizu T, Kawabata T, Nakamura M. Protective effect of a novel calcium blocker, S-312-d, on ischemic acute renal failure in rat. J Pharmacol Exp Ther. 1990 Nov;255(2):484-90. PubMed PMID: 2243338.