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MedKoo Cat#: 329104 | Name: Clonixin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clonixin, also known as lysine clonixinate and Deltar, is a non-steroidal anti-inflammatory used in the treatment of migraines.

Chemical Structure

Clonixin
Clonixin
CAS#17737-65-4

Theoretical Analysis

MedKoo Cat#: 329104

Name: Clonixin

CAS#: 17737-65-4

Chemical Formula: C13H11ClN2O2

Exact Mass: 262.0500

Molecular Weight: 262.69

Elemental Analysis: C, 59.44; H, 4.22; Cl, 13.49; N, 10.66; O, 12.18

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
10g USD 400.00 2 Weeks
25g USD 650.00 2 Weeks
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Related CAS #
No Data
Synonym
Clonixin; lysine clonixinate; Deltar; Chlonixin; Clonixic acid; Clonixine; Sch 10304; Sch-10304; Sch10304; CBA 93626; CBA93626; CBA-93626; NSC 335505; NSC335505; NSC-335505;
IUPAC/Chemical Name
2-(2'-Methyl-3'-chloro)anilinonicotinic acid
InChi Key
CLOMYZFHNHFSIQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H11ClN2O2/c1-8-10(14)5-2-6-11(8)16-12-9(13(17)18)4-3-7-15-12/h2-7H,1H3,(H,15,16)(H,17,18)
SMILES Code
O=C(O)C1=C(NC2=CC=CC(Cl)=C2C)N=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 262.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Russmann S, Dilger K, Trenk D, Nagyivanyi P, Jähnchen E. Effect of lysine clonixinate on the pharmacokinetics and anticoagulant activity of phenprocoumon. Arzneimittelforschung. 2001 Nov;51(11):891-5. PubMed PMID: 11765590. 2: Ferreira H, Lúcio M, Lima JL, Matos C, Reis S. Interaction of clonixin with EPC liposomes used as membrane models. J Pharm Sci. 2005 Jun;94(6):1277-87. PubMed PMID: 15858845. 3: Pallapies D, Muhs A, Bertram L, Rohleder G, Nagyiványi P, Peskar BA. Effects of single oral doses of lysine clonixinate and acetylsalicylic acid on platelet functions in man. Eur J Clin Pharmacol. 1996;49(5):351-4. PubMed PMID: 8866627. 4: Marcelín-Jiménez G, Angeles AC, García A, Morales M, Rivera L, Martín-Del-Campo A. Bioequivalence of 250 mg lysine clonixinate tablets after a single oral dose in a healthy female Mexican population under fasting conditions. Int J Clin Pharmacol Ther. 2010 May;48(5):349-54. PubMed PMID: 20420792. 5: González-Martin G, Cattan C, Zuñiga S. Pharmacokinetics of lysine clonixinate in children in postoperative care. Int J Clin Pharmacol Ther. 1996 Sep;34(9):396-9. PubMed PMID: 8880290. 6: Pineros I, Ballesteros P, Lastres JL. Extraction and LC determination of lysine clonixinate salt in water/oil microemulsions. J Pharm Biomed Anal. 2002 Feb 1;27(5):747-54. PubMed PMID: 11814716. 7: Krymchantowski AV, Peixoto P, Higashi R, Silva A Jr, Schutz V. Lysine clonixinate vs naproxen sodium for the acute treatment of migraine: a double-blind, randomized, crossover study. MedGenMed. 2005 Dec 14;7(4):69. PubMed PMID: 16614691; PubMed Central PMCID: PMC1681714. 8: Noronha VR, Gurgel GD, Alves LC, Noman-Ferreira LC, Mendonça LL, Aguiar EG, Abdo EN. Analgesic efficacy of lysine clonixinate, paracetamol and dipyrone in lower third molar extraction: a randomized controlled trial. Med Oral Patol Oral Cir Bucal. 2009 Aug 1;14(8):e411-5. PubMed PMID: 19415056. 9: Krymchantowski AV, Barbosa J. [Intravenous lysine clonixinate for the treatment of migraine: an open pilot study]. Arq Neuropsiquiatr. 1999 Sep;57(3A):606-9. Portuguese. PubMed PMID: 10667284. 10: Pallapies D, Salinger A, Meyer zum Gottesberge A, Atkins DJ, Rohleder G, Nagyiványi P, Peskar BA. Effects of lysine clonixinate and ketorolac tromethamine on prostanoid release from various rat organs incubated ex vivo. Life Sci. 1995;57(2):83-9. PubMed PMID: 7603299. 11: Krymchantowski AV, Carneiro H, Barbosa J, Jevoux C. Lysine clonixinate versus dipyrone (metamizole) for the acute treatment of severe migraine attacks: a single-blind, randomized study. Arq Neuropsiquiatr. 2008 Jun;66(2A):216-20. PubMed PMID: 18545786. 12: Krymchantowski AV, Barbosa JS, Cheim C, Alves LA. Oral lysine clonixinate in the acute treatment of migraine: a double-blind placebo-controlled study. Arq Neuropsiquiatr. 2001 Mar;59(1):46-9. PubMed PMID: 11299430. 13: Furst DE, Paulus HE. Lack of effect of rheumatoid arthritis on clonixin metabolism. Clin Pharmacol Ther. 1975 May;17(5):622-6. PubMed PMID: 1092517. 14: de los Santos AR, Di Girolamo G, Martí ML. Efficacy and tolerance of lysine clonixinate versus paracetamol/codeine following inguinal hernioplasty. Int J Tissue React. 1998;20(2):71-81. PubMed PMID: 9638504. 15: De los Santos AR, Martí MI, Espinosa D, Di Girolamo G, Vinacur JC, Casadei A. Lysine clonixinate vs. paracetamol/codeine in postepisiotomy pain. Acta Physiol Pharmacol Ther Latinoam. 1998;48(1):52-8. PubMed PMID: 9504193.