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MedKoo Cat#: 526137 | Name: Ro 09-0410

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 09-0410 is antivirus agent. It is suggested it binds to human rhinovirus type 2 (HRV-2) and made it inactive.

Chemical Structure

Ro 09-0410
Ro 09-0410
CAS#76554-66-0

Theoretical Analysis

MedKoo Cat#: 526137

Name: Ro 09-0410

CAS#: 76554-66-0

Chemical Formula: C19H20O4

Exact Mass: 312.1362

Molecular Weight: 312.37

Elemental Analysis: C, 73.06; H, 6.45; O, 20.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Ro 09-0410; Ro 090410; Ro 09 0410; Ro09-0410; Ro-09-0410; Ro090410;
IUPAC/Chemical Name
(E)-1-(4-ethoxy-2-methoxyphenyl)-3-(3-methoxyphenyl)prop-2-en-1-one
InChi Key
OQCMSXRDPOVQJZ-DHZHZOJOSA-N
InChi Code
InChI=1S/C19H20O4/c1-4-23-16-9-10-17(19(13-16)22-3)18(20)11-8-14-6-5-7-15(12-14)21-2/h5-13H,4H2,1-3H3/b11-8+
SMILES Code
O=C(/C=C/C1=CC=CC(OC)=C1)C2=C(OC)C=C(OCC)C=C2[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 312.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dewindt B, van Eemeren K, Andries K. Antiviral capsid-binding compounds can inhibit the adsorption of minor receptor rhinoviruses. Antiviral Res. 1994 Sep;25(1):67-72. doi: 10.1016/0166-3542(94)90094-9. PMID: 7811059. 2: Almela MJ, González ME, Carrasco L. Inhibitors of poliovirus uncoating efficiently block the early membrane permeabilization induced by virus particles. J Virol. 1991 May;65(5):2572-7. doi: 10.1128/JVI.65.5.2572-2577.1991. PMID: 1850030; PMCID: PMC240614. 3: Yasin SR, al-Nakib W, Tyrrell DA. Pathogenicity for humans of human rhinovirus type 2 mutants resistant to or dependent on chalcone Ro 09-0410. Antimicrob Agents Chemother. 1990 Jun;34(6):963-6. doi: 10.1128/AAC.34.6.963. PMID: 2168152; PMCID: PMC171738. 4: Ninomiya Y, Shimma N, Ishitsuka H. Comparative studies on the antirhinovirus activity and the mode of action of the rhinovirus capsid binding agents, chalcone amides. Antiviral Res. 1990 Feb;13(2):61-74. doi: 10.1016/0166-3542(90)90022-y. PMID: 2160796. 5: Al-Nakib W, Higgins PG, Barrow I, Tyrrell DA, Lenox-Smith I, Ishitsuka H. Intranasal chalcone, Ro 09-0410, as prophylaxis against rhinovirus infection in human volunteers. J Antimicrob Chemother. 1987 Dec;20(6):887-92. doi: 10.1093/jac/20.6.887. PMID: 3326874. 6: Ahmad AL, Dowsett AB, Tyrrell DA. Studies of rhinovirus resistant to an antiviral chalcone. Antiviral Res. 1987 Aug;8(1):27-39. doi: 10.1016/0166-3542(87)90085-4. PMID: 2825590. 7: Ishitsuka H, Ninomiya Y, Suhara Y. Molecular basis of drug resistance to new antirhinovirus agents. J Antimicrob Chemother. 1986 Oct;18 Suppl B:11-8. doi: 10.1093/jac/18.supplement_b.11. PMID: 3025150. 8: Ahmad AL, Tyrrell DA. Synergism between anti-rhinovirus antivirals: various human interferons and a number of synthetic compounds. Antiviral Res. 1986 Jul;6(4):241-52. doi: 10.1016/0166-3542(86)90005-7. PMID: 3017203. 9: Selway JW. Antiviral activity of flavones and flavans. Prog Clin Biol Res. 1986;213:521-36. PMID: 3012583. 10: Phillpotts RJ, Tyrrell DA. Rhinovirus colds. Br Med Bull. 1985 Oct;41(4):386-90. doi: 10.1093/oxfordjournals.bmb.a072081. PMID: 2996687. 11: Ninomiya Y, Aoyama M, Umeda I, Suhara Y, Ishitsuka H. Comparative studies on the modes of action of the antirhinovirus agents Ro 09-0410, Ro 09-0179, RMI-15,731, 4',6-dichloroflavan, and enviroxime. Antimicrob Agents Chemother. 1985 Apr;27(4):595-9. doi: 10.1128/AAC.27.4.595. PMID: 2988431; PMCID: PMC180102. 12: Diana GD, Otto MJ, McKinlay MA. Inhibitors of picornavirus uncoating as antiviral agents. Pharmacol Ther. 1985;29(3):287-97. doi: 10.1016/0163-7258(85)90005-1. PMID: 3014575. 13: Phillpotts RJ, Higgins PG, Willman JS, Tyrrell DA, Lenox-Smith I. Evaluation of the antirhinovirus chalcone Ro 09-0415 given orally to volunteers. J Antimicrob Chemother. 1984 Oct;14(4):403-9. doi: 10.1093/jac/14.4.403. PMID: 6094423. 14: Ninomiya Y, Ohsawa C, Aoyama M, Umeda I, Suhara Y, Ishitsuka H. Antivirus agent, Ro 09-0410, binds to rhinovirus specifically and stabilizes the virus conformation. Virology. 1984 Apr 30;134(2):269-76. doi: 10.1016/0042-6822(84)90296-4. PMID: 6100571. 15: Ishitsuka H, Ninomiya YT, Ohsawa C, Fujiu M, Suhara Y. Direct and specific inactivation of rhinovirus by chalcone Ro 09-0410. Antimicrob Agents Chemother. 1982 Oct;22(4):617-21. doi: 10.1128/AAC.22.4.617. PMID: 6295261; PMCID: PMC183802

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