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MedKoo Cat#: 526892 | Name: Pipoxazole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pipoxazole, also known as COR-32-24 amd COR3224, is an adrenergic receptor antagonist potentially for the treatment of depression.

Chemical Structure

Pipoxazole
Pipoxazole
CAS#91595-86-7

Theoretical Analysis

MedKoo Cat#: 526892

Name: Pipoxazole

CAS#: 91595-86-7

Chemical Formula: C14H20N4O

Exact Mass: 260.1637

Molecular Weight: 260.34

Elemental Analysis: C, 64.59; H, 7.74; N, 21.52; O, 6.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
COR-32-24; COR32-24; COR 32-24; COR-3224; COR3224; COR 3224. Pipoxazole
IUPAC/Chemical Name
4,5-Dihydro-5-(4-phenyl-1-piperazinylmethyl)-2-oxazolamine
InChi Key
XSZLHACSCSAKOF-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H20N4O/c15-14-16-10-13(19-14)11-17-6-8-18(9-7-17)12-4-2-1-3-5-12/h1-5,13H,6-11H2,(H2,15,16)
SMILES Code
NC1=NCC(CN2CCN(C3=CC=CC=C3)CC2)O1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 260.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Damaj MI, Urien S, Trouvin JH, Chanut E, Lambrey B, Jacquot C. In vivo evidence for carrier-mediated brain uptake of a new 2-amino-2-oxazoline (COR3224) via the purine transport system in rat. Brain Res. 1991 Jul 19;554(1-2):333-5. PubMed PMID: 1933316. 2: Damaj MI, Trouvin JH, Lambrey B, Jacquot C. Determination of a new 2-amino-2-oxazoline (COR 3224) in plasma and brain tissue of the rat by high-performance liquid chromatography with electrochemical detection. J Chromatogr. 1991 Feb 15;563(2):476-9. PubMed PMID: 2056013. 3: Neau B, Damaj I, Lambrey B, Akbaraly JP, Roux J, Perrissoud D, Jacquot J. COR3224--a new antidepressant: pharmacokinetics and metabolism in rat. Eur J Drug Metab Pharmacokinet. 1991;Spec No 3:77-9. PubMed PMID: 1820940. 4: Damaj MI, Trouvin JH, Lambrey B, Jacquot C. Kinetics and brain uptake of COR3224, a new 2-amino-2-oxazoline, in rats. Eur J Drug Metab Pharmacokinet. 1991;Spec No 3:52-6. PubMed PMID: 1820934. 5: Damaj MI, Trouvin JH, Lambrey B, Jacquot C. High-performance liquid chromatography of a new 2-amino-2-oxazoline: application to pharmacokinetic studies in dogs. J Pharm Sci. 1990 Jun;79(6):516-8. PubMed PMID: 2395095. 6: Jarry C, Bosc JJ, Ouhabi J, Carpy A. 2-Aminooxazolines, I: Crystal and molecular structure of 5-(1-aryl-4-piperazino)methyl-substituted derivatives with antidepressant activity. Arch Pharm (Weinheim). 1990 Mar;323(3):157-61. PubMed PMID: 2344261. 7: Bourin M, Creuzet MH, Jarry C, Colombel MC. A 2-amino-2-oxazoline derivative as an antidepressant in mice. Arzneimittelforschung. 1988 May;38(5):666-8. PubMed PMID: 3261982.