Synonym
Ripazepam; CCRIS 552; CI-683; Cl-68; BRN 0819726; Pyrazapon.
IUPAC/Chemical Name
1-Ethyl-1,4,5,6-tetrahydro-3-methyl-8-phenylpyrazolo(4,3-e)(1,4)diazepin-5-on
InChi Key
YFHYNLHGFKXAIQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H16N4O/c1-3-19-15-13(10(2)18-19)17-12(20)9-16-14(15)11-7-5-4-6-8-11/h4-8H,3,9H2,1-2H3,(H,17,20)
SMILES Code
O=C1CN=C(C2=CC=CC=C2)C(N(CC)N=C3C)=C3N1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
268.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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3: Baraldi PG, Manfredini S, Periotto V, Simoni D, Guarneri M, Borea PA. Synthesis and interaction of 5-(substituted-phenyl)-3-methyl-6,7-dihydropyrazolo[4,3-e] [1,4]diazepin-8(7H)-ones with benzodiazepine receptors in rat cerebral cortex. J Med Chem. 1985 May;28(5):683-5. PubMed PMID: 2985787.
4: Fitzgerald JE, de la Iglesia FA, McGuire EJ. Carcinogenicity studies in rodents and ripazepam, a minor tranquilizing agent. Fundam Appl Toxicol. 1984 Apr;4(2 Pt 1):178-90. PubMed PMID: 6724192.
5: Sanger DJ, Blackman DE. Effects of diazepam and ripazepam on two measures of adjunctive drinking in rats. Pharmacol Biochem Behav. 1976 Aug;5(2):139-42. PubMed PMID: 996049.
6: Sanger DJ, Blackman DE. Effects of chlordiazepoxide, ripazepam and d-amphetamine on conditioned acceleration of timing behaviour in rats. Psychopharmacology (Berl). 1976 Jul 28;48(2):209-15. PubMed PMID: 12524.
7: Schneyer JJ, Goodman LI, Borgen LA. Ripazepam (CI-683): double-blind comparison with placebo in anxious patients. J Clin Pharmacol. 1976 Jul;16(7):377-83. PubMed PMID: 780378.
