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MedKoo Cat#: 329008 | Name: Dopamine Hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dopamine Hydrochloride, also known as ASL-279 and Intropin, is an inotropic vasopressor agent and dopamine receptor agonist used in neurological diseases. Dopamine catecholamine neurotransmitter in the extrapyramidal system of the brain and important in regulating movement. Dopamine Hydrochloride used to treat acute heart failure, myocardial infarction and renal failure.

Chemical Structure

Dopamine Hydrochloride
Dopamine Hydrochloride
CAS#62-31-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 329008

Name: Dopamine Hydrochloride

CAS#: 62-31-7 (HCl)

Chemical Formula: C8H12ClNO2

Exact Mass: 0.0000

Molecular Weight: 189.64

Elemental Analysis: C, 50.67; H, 6.38; Cl, 18.69; N, 7.39; O, 16.87

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
25g USD 450.00 2 Weeks
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Related CAS #
62-31-7 (HCl); 51-61-6 (free base)
Synonym
Dopamine Hydrochloride; ASL-279; ASL 279; ASL279; Intropin; P 498; P-498; P498
IUPAC/Chemical Name
4-(2-aminoethyl)benzene-1,2-diol hydrochloride
InChi Key
CTENFNNZBMHDDG-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H
SMILES Code
OC1=CC=C(CCN)C=C1O.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# 62-31-7 (Dopamine Hydrochloride) 51-61-6 (Dopamine)

Preparing Stock Solutions

The following data is based on the product molecular weight 189.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Khan MS, Pandey S, Talib A, Bhaisare ML, Wu HF. Controlled delivery of dopamine hydrochloride using surface modified carbon dots for neuro diseases. Colloids Surf B Biointerfaces. 2015 Oct 1;134:140-6. doi: 10.1016/j.colsurfb.2015.06.006. Epub 2015 Jun 19. PubMed PMID: 26186107. 2: Zhai C, Li D, Li L, Sun F, Ma H, Liu X. Experimental and theoretical study on the hydrogen bonding between dopamine hydrochloride and N,N-dimethyl formamide. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Jun 15;145:500-4. doi: 10.1016/j.saa.2015.03.024. Epub 2015 Mar 12. Erratum in: Spectrochim Acta A Mol Biomol Spectrosc. 2015 Nov;150:1015. PubMed PMID: 25801441. 3: Xiao XD, Shi L, Guo LH, Wang JW, Zhang X. Determination of dopamine hydrochloride by host-guest interaction based on water-soluble pillar[5]arene. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Aug 27;173:6-12. doi: 10.1016/j.saa.2016.08.050. [Epub ahead of print] PubMed PMID: 27588725. 4: Gosliga JM, Barter LS. Cardiovascular effects of dopamine hydrochloride and phenylephrine hydrochloride in healthy isoflurane-anesthetized New Zealand White rabbits (Oryctolagus cuniculus). Am J Vet Res. 2015 Feb;76(2):116-21. doi: 10.2460/ajvr.76.2.116. PubMed PMID: 25629908. 5: Callear SK, Johnston A, McLain SE, Imberti S. Conformation and interactions of dopamine hydrochloride in solution. J Chem Phys. 2015 Jan 7;142(1):014502. doi: 10.1063/1.4904291. PubMed PMID: 25573567. 6: Di Gioia S, Trapani A, Mandracchia D, De Giglio E, Cometa S, Mangini V, Arnesano F, Belgiovine G, Castellani S, Pace L, Lavecchia MA, Trapani G, Conese M, Puglisi G, Cassano T. Intranasal delivery of dopamine to the striatum using glycol chitosan/sulfobutylether-β-cyclodextrin based nanoparticles. Eur J Pharm Biopharm. 2015 Aug;94:180-93. doi: 10.1016/j.ejpb.2015.05.019. Epub 2015 May 30. PubMed PMID: 26032293. 7: Hong JM, Cho AR, Choi SA. Accidental intrathecal injection of dopamine hydrochloride resulting in analgesic effects. Korean J Anesthesiol. 2014 Dec;67(Suppl):S49-50. doi: 10.4097/kjae.2014.67.S.S49. PubMed PMID: 25598904; PubMed Central PMCID: PMC4295978. 8: Achterberg EJ, van Kerkhof LW, Servadio M, van Swieten MM, Houwing DJ, Aalderink M, Driel NV, Trezza V, Vanderschuren LJ. Contrasting Roles of Dopamine and Noradrenaline in the Motivational Properties of Social Play Behavior in Rats. Neuropsychopharmacology. 2016 Feb;41(3):858-68. doi: 10.1038/npp.2015.212. PubMed PMID: 26174597; PubMed Central PMCID: PMC4707831. 9: Mercante LA, Pavinatto A, Iwaki LE, Scagion VP, Zucolotto V, Oliveira ON Jr, Mattoso LH, Correa DS. Electrospun polyamide 6/poly(allylamine hydrochloride) nanofibers functionalized with carbon nanotubes for electrochemical detection of dopamine. ACS Appl Mater Interfaces. 2015 Mar 4;7(8):4784-90. doi: 10.1021/am508709c. Epub 2015 Feb 17. PubMed PMID: 25644325. 10: Wang W, Zhao L, Bai F, Zhang T, Dong H, Liu L. The protective effect of dopamine against OGD/R injury-induced cell death in HT22 mouse hippocampal cells. Environ Toxicol Pharmacol. 2016 Mar;42:176-82. doi: 10.1016/j.etap.2016.01.020. Epub 2016 Jan 27. PubMed PMID: 26867202. 11: Li H, Wu X. Silver nanoparticles-enhanced rare earth co-luminescence effect of Tb(III)-Y(III)-dopamine system. Talanta. 2015 Jun 1;138:203-8. doi: 10.1016/j.talanta.2015.02.023. Epub 2015 Feb 20. PubMed PMID: 25863392. 12: Krishna G, Gopalakrishnan G, Goel S. In vitro and in vivo genotoxicity assessment of the dopamine receptor antagonist molindone hydrochloride. Environ Mol Mutagen. 2016 May;57(4):288-98. doi: 10.1002/em.22007. Epub 2016 Apr 4. PubMed PMID: 27040600. 13: Mohamed GG, Nour el-Dien FA, el-Nahas RG. New copper(II) complexes with dopamine hydrochloride and vanillymandelic acid: spectroscopic and thermal characterization. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Oct 15;81(1):489-97. doi: 10.1016/j.saa.2011.06.042. Epub 2011 Jun 23. PubMed PMID: 21795104. 14: Wu SF, Xu G, Stanley D, Huang J, Ye GY. Dopamine modulates hemocyte phagocytosis via a D1-like receptor in the rice stem borer, Chilo suppressalis. Sci Rep. 2015 Jul 16;5:12247. doi: 10.1038/srep12247. PubMed PMID: 26179416; PubMed Central PMCID: PMC4503959. 15: Cho S, Kim SH. Hydroxide ion-mediated synthesis of monodisperse dopamine-melanin nanospheres. J Colloid Interface Sci. 2015 Nov 15;458:87-93. doi: 10.1016/j.jcis.2015.06.051. Epub 2015 Jul 10. PubMed PMID: 26210098.

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