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MedKoo Cat#: 328922 | Name: Enflurane

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Enflurane, also known as Efrane and NSC-115944, is an inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.

Chemical Structure

Enflurane
Enflurane
CAS#13838-16-9

Theoretical Analysis

MedKoo Cat#: 328922

Name: Enflurane

CAS#: 13838-16-9

Chemical Formula: C3H2ClF5O

Exact Mass: 183.9714

Molecular Weight: 184.49

Elemental Analysis: C, 19.53; H, 1.09; Cl, 19.22; F, 51.49; O, 8.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Enflurane; NSC-115944; NSC 115944; NSC115944; Efrane; Ethrane
IUPAC/Chemical Name
2-chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
InChi Key
JPGQOUSTVILISH-UHFFFAOYSA-N
InChi Code
InChI=1S/C3H2ClF5O/c4-1(5)3(8,9)10-2(6)7/h1-2H
SMILES Code
FC(Cl)C(F)(OC(F)F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 184.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Andrade LA, Silla JM, Stephens SL, Marat K, da Cunha EF, Ramalho TC, van Wijngaarden J, Freitas MP. Conformational Exploration of Enflurane in Solution and in a Biological Environment. J Phys Chem A. 2015 Oct 29;119(43):10735-42. doi: 10.1021/acs.jpca.5b08087. Epub 2015 Oct 19. PubMed PMID: 26461140. 2: Liu H, Weng H. Up-regulation of Alzheimer's disease-associated proteins may cause enflurane anesthesia induced cognitive decline in aged rats. Neurol Sci. 2014 Feb;35(2):185-9. doi: 10.1007/s10072-013-1474-x. Epub 2013 Aug 11. PubMed PMID: 23934553. 3: Hung O. From the Journal archives: Early clinical evaluation of enflurane: the cost of progress. Can J Anaesth. 2014 Mar;61(3):269-72. doi: 10.1007/s12630-013-0091-8. Epub 2013 Dec 7. PubMed PMID: 24318728. 4: Zierkiewicz W, Czarnik-Matusewicz B, Michalska D. Blue shifts and unusual intensity changes in the infrared spectra of the enflurane···acetone complexes: spectroscopic and theoretical studies. J Phys Chem A. 2011 Oct 20;115(41):11362-8. doi: 10.1021/jp205081r. Epub 2011 Sep 13. PubMed PMID: 21913646. 5: Pérez C, Caballero-Mancebo E, Lesarri A, Cocinero EJ, Alkorta I, Suenram RD, Grabow JU, Pate BH. The Conformational Map of Volatile Anesthetics: Enflurane Revisited. Chemistry. 2016 Jul 4;22(28):9804-11. doi: 10.1002/chem.201601201. Epub 2016 Jun 3. PubMed PMID: 27258776. 6: Dogan Z, Senoglu N, Yildiz H, Coskuner I, Ugur N, Biter E, Oksuz H. Comparison of enflurane and propofol in electroconvulsive therapy, a randomized crossover open preliminary study on seizure duration and anaesthetic recovery. Rev Bras Anestesiol. 2011 Sep-Oct;61(5):582-90, 319-23. doi: 10.1016/S0034-7094(11)70069-1. English, Portuguese, Spanish. Erratum in: Rev Bras Anestesiol. 2011 Nov-Dec;61(6):832. PubMed PMID: 21920208. 7: Dogan Z, Orhan FO, Oksuz H, Senoglu N, Yildiz H, Ugur N. Effects of enflurane and propofol on seizure duration and recovery profiles in electroconvulsive therapy. Middle East J Anaesthesiol. 2011 Feb;21(1):77-81. Retraction in: Middle East J Anaesthesiol. 2012 Feb;21(4):659. PubMed PMID: 21991737. 8: Guo J, Zhou C, Liang P, Huang H, Li F, Chen X, Liu J. Comparison of subarachnoid anesthetic effect of emulsified volatile anesthetics in rats. Int J Clin Exp Pathol. 2014 Dec 1;7(12):8748-55. eCollection 2014. PubMed PMID: 25674241; PubMed Central PMCID: PMC4313979. 9: Murakami M, Niwa H, Kushikata T, Watanabe H, Hirota K, Ono K, Ohba T. Inhalation anesthesia is preferable for recording rat cardiac function using an electrocardiogram. Biol Pharm Bull. 2014;37(5):834-9. PubMed PMID: 24790005. 10: Zierkiewicz W, Zaleśny R, Hobza P. On the nature of unusual intensity changes in the infrared spectra of the enflurane···acetone complexes. Phys Chem Chem Phys. 2013 Apr 28;15(16):6001-7. doi: 10.1039/c3cp50385b. Epub 2013 Mar 15. PubMed PMID: 23493886. 11: Zierkiewicz W, Wieczorek R, Hobza P, Michalska D. Halogen bonded complexes between volatile anaesthetics (chloroform, halothane, enflurane, isoflurane) and formaldehyde: a theoretical study. Phys Chem Chem Phys. 2011 Mar 21;13(11):5105-13. doi: 10.1039/c0cp02085k. Epub 2011 Feb 3. PubMed PMID: 21290074. 12: Zierkiewicz W, Michalska D, Zeegers-Huyskens T. Theoretical studies of the interaction between enflurane and water. J Mol Model. 2013 Mar;19(3):1399-405. doi: 10.1007/s00894-012-1678-7. Epub 2012 Dec 5. PubMed PMID: 23212236; PubMed Central PMCID: PMC3578735. 13: Wang X, Zhang XF. Enflurane requirement for blocking adrenergic responses to incision in infants and children. World J Pediatr. 2008 Feb;4(1):49-52. doi: 10.1007/s12519-008-0010-1. PubMed PMID: 18402253. 14: Deng XS, Simpson VJ. Determination of volatile anesthetics isoflurane and enflurane in mouse brain tissues using gas chromatography-mass spectrometry. J Pharmacol Toxicol Methods. 2004 Mar-Apr;49(2):131-6. PubMed PMID: 14990338. 15: Hauet N, Artzner F, Boucher F, Grabielle-Madelmont C, Cloutier I, Keller G, Lesieur P, Durand D, Paternostre M. Interaction between artificial membranes and enflurane, a general volatile anesthetic: DPPC-enflurane interaction. Biophys J. 2003 May;84(5):3123-37. PubMed PMID: 12719242; PubMed Central PMCID: PMC1302873.