Synonym
Selepressin; FE 202158; FE202158; FE-202158. [Phe(2),Ile(3), Hgn(4),Orn(iPr)(8)]vasopressin
IUPAC/Chemical Name
(S)-N-((S)-1-((2-amino-2-oxoethyl)amino)-5-(isopropylamino)-1-oxopentan-2-yl)-1-((4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(4-amino-4-oxobutyl)-16-benzyl-13-((S)-sec-butyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)pyrrolidine-2-carboxamide
SMILES Code
O=C([C@H]1N(C([C@@H](NC([C@H](CC(N)=O)NC([C@H](CCCC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC2=CC=CC=C2)N3)=O)=O)=O)=O)CSSC[C@H](N)C3=O)=O)CCC1)N[C@@H](CCCNC(C)C)C(NCC(N)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
1,048.29
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Stolk RF, van der Poll T, Angus DC, van der Hoeven JG, Pickkers P, Kox M. Potentially Inadvertent Immunomodulation: Norepinephrine Use in Sepsis. Am J Respir Crit Care Med. 2016 Sep 1;194(5):550-8. doi: 10.1164/rccm.201604-0862CP. PubMed PMID: 27398737.
2: Heming N, Lamothe L, Ambrosi X, Annane D. Emerging drugs for the treatment of sepsis. Expert Opin Emerg Drugs. 2016;21(1):27-37. doi: 10.1517/14728214.2016.1132700. Review. PubMed PMID: 26751198.
3: Asfar P, Russell JA, Tuckermann J, Radermacher P. Selepressin in Septic Shock: A Step Toward Decatecholaminization? Crit Care Med. 2016 Jan;44(1):234-6. doi: 10.1097/CCM.0000000000001441. PubMed PMID: 26672929.
4: He X, Su F, Taccone FS, Laporte R, Kjølbye AL, Zhang J, Xie K, Moussa MD, Reinheimer TM, Vincent JL. A Selective V(1A) Receptor Agonist, Selepressin, Is Superior to Arginine Vasopressin and to Norepinephrine in Ovine Septic Shock. Crit Care Med. 2016 Jan;44(1):23-31. doi: 10.1097/CCM.0000000000001380. PubMed PMID: 26496451; PubMed Central PMCID: PMC4684247.
5: Vincent JL. Emerging therapies for the treatment of sepsis. Curr Opin Anaesthesiol. 2015 Aug;28(4):411-6. doi: 10.1097/ACO.0000000000000210. Review. PubMed PMID: 26087275.
6: Marks JA, Pascual JL. Selepressin in septic shock: sharpening the VASST effects of vasopressin?*. Crit Care Med. 2014 Jul;42(7):1747-8. doi: 10.1097/CCM.0000000000000420. PubMed PMID: 24933060.
7: Maybauer MO, Maybauer DM, Enkhbaatar P, Laporte R, Wiśniewska H, Traber LD, Lin C, Fan J, Hawkins HK, Cox RA, Wiśniewski K, Schteingart CD, Landry DW, Rivière PJ, Traber DL. The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis*. Crit Care Med. 2014 Jul;42(7):e525-33. doi: 10.1097/CCM.0000000000000300. PubMed PMID: 24674922; PubMed Central PMCID: PMC4346299.
8: Boucheix OB, Milano SP, Henriksson M, Reinheimer TM. Selepressin, a new V1A receptor agonist: hemodynamic comparison to vasopressin in dogs. Shock. 2013 Jun;39(6):533-8. doi: 10.1097/SHK.0b013e31828aac4b. PubMed PMID: 23429645.
