Synonym
ON-013100; ON 013100; ON013100.
IUPAC/Chemical Name
(E)-5-(((2,4,6-Trimethoxystyryl)sulfonyl)methyl)-2-methoxyphenol
InChi Key
GHPUSRLWNSTQIK-BQYQJAHWSA-N
InChi Code
InChI=1S/C19H22O7S/c1-23-14-10-18(25-3)15(19(11-14)26-4)7-8-27(21,22)12-13-5-6-17(24-2)16(20)9-13/h5-11,20H,12H2,1-4H3/b8-7+
SMILES Code
OC1=CC(CS(=O)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O)=CC=C1OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
ON-013100, an antineoplastic drug, acts a mitotic inhibitor that could inhibit Cyclin D1 expression.
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMSO |
25.0 |
63.38 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
394.44
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
1: Cho SY, Cosenza SC, Pallela V, Panda G, Reddy MV, Reddy EP, Roboz J.
Determination of the glucuronide metabolite of ON 013100, a benzylstyrylsulfone
antineoplastic drug, in colon cancer cells using LC/MS/MS. J Pharm Biomed Anal.
2013 Mar 5;75:138-44. doi: 10.1016/j.jpba.2012.11.022. Epub 2012 Nov 23. PubMed
PMID: 23261806.
2: Nuthalapati S, Zhou Q, Guo P, Lv H, Cosenza S, Reddy MV, Reddy EP, Gallo JM.
Preclinical pharmacokinetic and pharmacodynamic evaluation of novel anticancer
agents, ON01910.Na (Rigosertib, Estybon™) and ON013105, for brain tumor
chemotherapy. Pharm Res. 2012 Sep;29(9):2499-511. doi: 10.1007/s11095-012-0780-y.
Epub 2012 Jun 8. PubMed PMID: 22678771.
3: Park IW, Reddy MV, Reddy EP, Groopman JE. Evaluation of novel cell cycle
inhibitors in mantle cell lymphoma. Oncogene. 2007 Aug 16;26(38):5635-42. Epub
2007 Mar 19. PubMed PMID: 17369860.
