MedKoo Cat#: 326996 | Name: Cilansetron

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cilansetron, also known as DU-123265, KC-9946, is a 5-HT3 antagonist potentially for the treatment of irritable bowel syndrome. Cilansetron acts at its site of absorption to antagonize the sensitivity of mesenteric afferent fibres to 5-hydroxytryptamine in the rat jejunum.

Chemical Structure

Cilansetron
Cilansetron
CAS#120635-74-7

Theoretical Analysis

MedKoo Cat#: 326996

Name: Cilansetron

CAS#: 120635-74-7

Chemical Formula: C20H21N3O

Exact Mass: 319.1685

Molecular Weight: 319.41

Elemental Analysis: C, 75.21; H, 6.63; N, 13.16; O, 5.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Cilansetron; DU-123265; KC-9946; DU123265; KC9946.
IUPAC/Chemical Name
(10R)-10-[(2-methyl-1H-imidazol-1-yl)methyl]-5,6,9,10-tetrahydro-4H-pyrido(3,2,1-jk)carbazol-11-one
InChi Key
VQXNCPYVIJRURD-NNJIEVJOSA-N
InChi Code
InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,8-9,11,15,18H,3,5,7,10,12H2,1H3/t15-,18?/m1/s1
SMILES Code
O=C1[C@@H](CN2C=CN=C2C)CC=C3N4C5=C(C=CC=C5CCC4)C13
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 319.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Painsipp E, Shahbazian A, Holzer P. Alosetron, cilansetron and tegaserod modify mesenteric but not colonic blood flow in rats. Br J Pharmacol. 2009 Nov;158(5):1210-26. doi: 10.1111/j.1476-5381.2009.00392.x. Epub 2009 Sep 25. PubMed PMID: 19785647; PubMed Central PMCID: PMC2782331. 2: Stacher G. Cilansetron in the treatment of diarrhea-predominant irritable bowel syndrome? Expert Rev Gastroenterol Hepatol. 2007 Oct;1(1):15-27. doi: 10.1586/17474124.1.1.15. Review. PubMed PMID: 19072430. 3: Olden KW, Crowell MD. Cilansetron. Drugs Today (Barc). 2005 Oct;41(10):661-6. Review. PubMed PMID: 16389408. 4: Cilansetron: KC 9946. Drugs R D. 2005;6(3):169-73. Review. PubMed PMID: 15869320. 5: Chey WD, Cash BD. Cilansetron: a new serotonergic agent for the irritable bowel syndrome with diarrhoea. Expert Opin Investig Drugs. 2005 Feb;14(2):185-93. Review. PubMed PMID: 15757394. 6: Stacher G. Cilansetron. Solvay. Curr Opin Investig Drugs. 2001 Oct;2(10):1432-6. Review. PubMed PMID: 11890360. 7: Stacher G, Weber U, Stacher-Janotta G, Bauer P, Huber K, Holzäpfel A, Krause G, Steinborn C. Effects of the 5-HT3 antagonist cilansetron vs placebo on phasic sigmoid colonic motility in healthy man: a double-blind crossover trial. Br J Clin Pharmacol. 2000 May;49(5):429-36. PubMed PMID: 10792200; PubMed Central PMCID: PMC2014951. 8: Hillsley K, Eeckhout C, Grundy D. Cilansetron acts at its site of absorption to antagonize the sensitivity of mesenteric afferent fibres to 5-hydroxytryptamine in the rat jejunum. Neurosci Lett. 2000 Jan 14;278(3):137-40. PubMed PMID: 10653012.