Fenbufen | Cinopal | CL-82204 | CAS#36330-85-5 | Non-Steroidal Anti-Inflammatory

MedKoo Cat#: 328906 | Name: Fenbufen

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fenbufen, also known as Cinopal and CL-82204, is an arylpropionic acid derivative belonging to the group of non-steroidal anti-inflammatory drugs.

Chemical Structure

Fenbufen

CAS#36330-85-5

Theoretical Analysis

MedKoo Cat#: 328906

Name: Fenbufen

CAS#: 36330-85-5

Chemical Formula: C16H14O3

Exact Mass: 254.0943

Molecular Weight: 254.29

Elemental Analysis: C, 75.58; H, 5.55; O, 18.88

Price and Availability

Size	Price	Availability	Quantity
5g	USD 250.00	2 Weeks
25g	USD 650.00	2 Weeks

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Related CAS #

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Synonym

Fenbufen; Cinopal; Lederfen; Bufemid; CL-82204; CL 82204; CL82204; NSC757812; NSC 757812; NSC-757812

IUPAC/Chemical Name

4-([1,1'-biphenyl]-4-yl)-4-oxobutanoic acid

InChi Key

ZPAKPRAICRBAOD-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19)

SMILES Code

O=C(O)CCC(C1=CC=C(C2=CC=CC=C2)C=C1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 254.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Syed M, Skonberg C, Hansen SH. Inhibition of ATP synthesis by fenbufen and its conjugated metabolites in rat liver mitochondria. Toxicol In Vitro. 2016 Mar;31:23-9. doi: 10.1016/j.tiv.2015.11.013. Epub 2015 Nov 21. PubMed PMID: 26612354. 2: Ferrone V, Carlucci M, Palumbo P, Carlucci G. Bioanalytical method development for quantification of ulifloxacin, fenbufen and felbinac in rat plasma by solid-phase extraction (SPE) and HPLC with PDA detection. J Pharm Biomed Anal. 2016 May 10;123:205-12. doi: 10.1016/j.jpba.2016.01.062. Epub 2016 Feb 1. PubMed PMID: 26898973. 3: Dhaneshwar S, Kusurkar M, Bodhankar S, Bihani G. Carrier-linked mutual prodrugs of biphenylacetic acid as a promising alternative to bioprecursor fenbufen: design, kinetics, and pharmacological studies. Inflammopharmacology. 2014 Aug;22(4):235-50. doi: 10.1007/s10787-013-0194-4. Epub 2013 Nov 1. PubMed PMID: 24178955. 4: Huang YC, Chang YC, Yeh CN, Yu CS. Synthesis and Biological Evaluation of an (18)Fluorine-Labeled COX Inhibitor--[(18)F]Fluorooctyl Fenbufen Amide--For Imaging of Brain Tumors. Molecules. 2016 Mar 21;21(3):387. doi: 10.3390/molecules21030387. PubMed PMID: 27007363. 5: Yang Y, Gao H. Density functional theory study on the molecular structure and vibration spectra of fenbufen. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Jan 15;101:119-26. doi: 10.1016/j.saa.2012.09.034. Epub 2012 Sep 26. PubMed PMID: 23099169. 6: Huang HL, Yeh CN, Lee WY, Huang YC, Chang KW, Lin KJ, Tien SF, Su WC, Yang CH, Chen JT, Lin WJ, Fan SS, Yu CS. [123I]Iodooctyl fenbufen amide as a SPECT tracer for imaging tumors that over-express COX enzymes. Biomaterials. 2013 Apr;34(13):3355-65. doi: 10.1016/j.biomaterials.2013.01.050. Epub 2013 Feb 4. PubMed PMID: 23384791. 7: Lin KI, Yang CH, Huang CW, Jian JY, Huang YC, Yu CS. Synthesis and structure-activity relationships of fenbufen amide analogs. Molecules. 2010 Dec 2;15(12):8796-803. doi: 10.3390/molecules15128796. PubMed PMID: 21127465. 8: Su YH, Chiang LW, Jeng KC, Huang HL, Chen JT, Lin WJ, Huang CW, Yu CS. Solution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1320-4. doi: 10.1016/j.bmcl.2011.01.068. Epub 2011 Jan 22. PubMed PMID: 21315586. 9: Carriazo D, del Arco M, Fernández A, Martín C, Rives V. Inclusion and release of fenbufen in mesoporous silica. J Pharm Sci. 2010 Aug;99(8):3372-80. doi: 10.1002/jps.22096. PubMed PMID: 20232455. 10: De Sarro G, Renne S, Nava F, De Sarro A. Fenbufen pretreatment potentiates the anticonvulsant activity of CPPene and NBQX in DBA/2 mice. J Pharm Pharmacol. 1994 Dec;46(12):1017-22. PubMed PMID: 7714713. 11: Naora K, Katagiri Y, Ichikawa N, Hayashibara M, Iwamoto K. Enhanced entry of ciprofloxacin into the rat central nervous system induced by fenbufen. J Pharmacol Exp Ther. 1991 Sep;258(3):1033-7. PubMed PMID: 1890610. 12: Naora K, Katagiri Y, Ichikawa N, Hayashibara M, Iwamoto K. A minor possibility of pharmacokinetic interaction between enoxacin and fenbufen in rats. J Pharmacobiodyn. 1990 Feb;13(2):90-6. PubMed PMID: 2384853. 13: Crossley RJ. Side effect and safety data for fenbufen. Am J Med. 1983 Oct 31;75(4B):84-90. PubMed PMID: 6227235. 14: Chiccarelli FS, Eisner HJ, Van Lear GE. Disposition and metabolism of fenbufen in several laboratory animals. Arzneimittelforschung. 1980;30(4A):707-15. PubMed PMID: 6776965. 15: Moore RA, Derry S, McQuay HJ. Single dose oral fenbufen for acute postoperative pain in adults. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD007547. doi: 10.1002/14651858.CD007547.pub2. Review. PubMed PMID: 19821427; PubMed Central PMCID: PMC4175557.