Synonym
Propiram fumarate; Algeril; BAY 4503; Dirame; EINECS 237-270-6; FBA 4503.
IUPAC/Chemical Name
N-(1-Methyl-2-piperidinoethyl)-N-2-pyridylpropionamide fumarate
InChi Key
WQTLOZFMTGYQDX-WLHGVMLRSA-N
InChi Code
InChI=1S/C16H25N3O.C4H4O4/c1-3-16(20)19(15-9-5-6-10-17-15)14(2)13-18-11-7-4-8-12-18;5-3(6)1-2-4(7)8/h5-6,9-10,14H,3-4,7-8,11-13H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
SMILES Code
CCC(N(C(C)CN1CCCCC1)C2=NC=CC=C2)=O.O=C(O)/C=C/C(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
391.47
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Desjardins PJ, Cooper SA, Gallegos TL, Allwein JB, Reynolds DC, Kruger GO, Beaver WT. The relative analgesic efficacy of propiram fumarate, codeine, aspirin, and placebo in post-impaction dental pain. J Clin Pharmacol. 1984 Jan;24(1):35-42. PubMed PMID: 6368614.
2: Sunshine A, Laska EM, Olson NZ, Colon A, Gonzalez L, Tirado S. Analgesic effects of oral propiram fumarate, codeine sulfate and placebo in postoperative pain. Pharmacotherapy. 1983 Sep-Oct;3(5):299-303. PubMed PMID: 6359083.
3: Wilson RS, Landers JH. Use of a new oral analgesic, propiram fumarate, in treating postoperative ocular pain. Ann Ophthalmol. 1982 Dec;14(12):1172-4. PubMed PMID: 7165237.
4: Korduba CA, Veals J, Radwanski E, Symchowicz S, Chung M. Bioavailability of orally administered propiram fumarate in humans. J Pharm Sci. 1981 May;70(5):521-3. PubMed PMID: 7241356.
5: Finch JS. Analgesic comparison of propiram fumarate with pentazocine, codeine, and placebo in postsurgical pain. J Clin Pharmacol. 1980 Nov-Dec;20(11-12):689-92. PubMed PMID: 7014656.
6: Kakizawa T, Kawachi H, Yamamoto H, Komiya Y. [Clinical evaluation of Bayer-4503 (propiram fumarate) in oral surgery]. Nihon Koku Geka Gakkai Zasshi. 1972;18(4):456-9. Japanese. PubMed PMID: 4511502.
7: Suzuki M, Yusa T, Shima T, Iwatsuki K. [Propiram fumarate, a new analgesic]. Masui. 1971 Sep;20(10):909-11. Japanese. PubMed PMID: 4942667.
