Propanidid | CAS#1421-14-3 | GABAA receptor agonist|

MedKoo Cat#: 526058 | Name: Propanidid

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Propanidid, also known as Sombrevin, is a short-acting phenylacetate general anesthetic and GABAA receptor agonist. Propanidid is an intravenous anesthetic with transient action and rapid recovery features, but it is clinically unacceptable due to its side effects.

Chemical Structure

Propanidid

CAS#1421-14-3

Theoretical Analysis

MedKoo Cat#: 526058

Name: Propanidid

CAS#: 1421-14-3

Chemical Formula: C18H27NO5

Exact Mass: 337.1889

Molecular Weight: 337.42

Elemental Analysis: C, 64.07; H, 8.07; N, 4.15; O, 23.71

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 450.00
200mg	USD 650.00
500mg	USD 950.00

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Related CAS #

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Synonym

Propanidid; Epontol; Fabantol; Fabontal; FBA 1420; BAY-1420, Sombrevin; TH-2180; WH 5668.

IUPAC/Chemical Name

propyl 2-(4-(2-(diethylamino)-2-oxoethoxy)-3-methoxyphenyl)acetate

InChi Key

KEJXLQUPYHWCNM-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H27NO5/c1-5-10-23-18(21)12-14-8-9-15(16(11-14)22-4)24-13-17(20)19(6-2)7-3/h8-9,11H,5-7,10,12-13H2,1-4H3

SMILES Code

O=C(OCCC)CC1=CC=C(OCC(N(CC)CC)=O)C(OC)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 337.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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PMID: 34762632. 5: Cenani A, Brosnan RJ, Knych HK. In vitro and in vivo GABAA Receptor Interaction of the Propanidid Metabolite 4-(2-[Diethylamino]-2-Oxoethoxy)-3-Methoxy-Benzeneacetic Acid. Pharmacology. 2019;103(1-2):10-16. doi: 10.1159/000493753. Epub 2018 Oct 17. PMID: 30332672. 6: Wang S, Liu Q, Li X, Zhao X, Qiu L, Lin J. Possible binding sites and interactions of propanidid and AZD3043 within the γ-aminobutyric acid type A receptor (GABAAR). J Biomol Struct Dyn. 2018 Nov;36(15):3926-3937. doi: 10.1080/07391102.2017.1403959. Epub 2017 Nov 29. PMID: 29125020. 7: Zhang H, Xu X, Chen Y, Qiu Y, Liu X, Liu BF, Zhang G. Phenyl acetate derivatives, fluorine-substituted on the phenyl group, as rapid recovery hypnotic agents with reflex depression. Eur J Med Chem. 2015 Jan 7;89:524-39. doi: 10.1016/j.ejmech.2014.10.073. Epub 2014 Oct 28. PMID: 25462263. 8: Zhang H, Xu X, Chen Y, Qiu Y, Liu X, Liu BF, Zhang G. Synthesis and evaluation of fluorine-substituted phenyl acetate derivatives as ultra-short recovery sedative/hypnotic agents. PLoS One. 2014 May 5;9(5):e96518. doi: 10.1371/journal.pone.0096518. PMID: 24796695; PMCID: PMC4010497. 9: Brown TC. Thiopentone and its challengers. Paediatr Anaesth. 2013 Oct;23(10):957-8. doi: 10.1111/pan.12083. Epub 2012 Dec 6. PMID: 23216953. 10: Egan TD, Obara S, Jenkins TE, Jaw-Tsai SS, Amagasu S, Cook DR, Steffensen SC, Beattie DT. AZD-3043: a novel, metabolically labile sedative-hypnotic agent with rapid and predictable emergence from hypnosis. Anesthesiology. 2012 Jun;116(6):1267-77. doi: 10.1097/ALN.0b013e31825685a6. PMID: 22531340; PMCID: PMC4056591. 11: Görög S, Babják M, Balogh G, Brlik J, Csehi A, Dravecz F, Gasdag M, Horváth P, Laukó A, Varga K. Drug impurity profiling strategies. Talanta. 1997 Sep;44(9):1517-26. PMID: 18966892. 12: Ball C, Westhorpe R. Intravenous Induction Agents--propanidid. Anaesth Intensive Care. 2002 Jun;30(3):261. doi: 10.1177/0310057X0203000301. PMID: 12075631. 13: Raeva S, Vainberg N, Dubinin V. Analysis of spontaneous activity patterns of human thalamic ventrolateral neurons and their modifications due to functional brain changes. Neuroscience. 1999 Jan;88(2):365-76. doi: 10.1016/s0306-4522(98)00228-0. PMID: 10197760. 14: Buravtsev VA, Medvinskiĭ ID. Readaptatsiia posle total'noĭ vnutrivennoĭ anestezii v khirurgii odnogo dnia [Readaptation after total intravenous anesthesia in one-day surgery]. Anesteziol Reanimatol. 1997 Jan-Feb;(1):67-9. Russian. PMID: 9173826. 15: Feldman S, Karalliedde L. Drug interactions with neuromuscular blockers. Drug Saf. 1996 Oct;15(4):261-73. doi: 10.2165/00002018-199615040-00004. PMID: 8905251. 16: Klockgether-Radke A, Kersten J, Schröder T, Stafforst D, Kettler D, Hellige G. Anästhesie mit Propanidid in liposomaler Zubereitung. Eine experimentelle Studie am Schwein [Anesthesia with propanidid in a liposomal preparation. An experimental study in swine]. Anaesthesist. 1995 Aug;44(8):573-80. German. doi: 10.1007/s001010050191. PMID: 7573906. 17: Sütterlin R. Anästhesiologische Wirksamkeit von Propanidid als Liposomendispersion [Comments on the paper by H. Habazettl et al. The anesthetic usefulness of propanidid as a liposome dispersion]. Anaesthesist. 1994 Jan;43(1):50-2. German. PMID: 8122725. 18: Rózsa A, Lipcsey A. Az electroconvulsiv kezelés transcranialis Doppler sonographiás módszerrel megfigyelt hatása az arteria cerebri media keringésére [Transcranial Doppler sonographic study of the effect of electroconvulsive therapy on the circulation in the median cerebral artery]. Orv Hetil. 1992 Oct 18;133(42):2679-82. Hungarian. PMID: 1437096. 19: Habazettl H, Vollmar B, Röhrich F, Conzen P, Doenicke A, Baethmann A. Anästhesiologische Wirksamkeit von Propanidid als Liposomendispersion. Eine experimentelle studie mit ratten [Anesthesiologic efficacy of propanidid as a liposome dispersion. An experimental study with rats]. Anaesthesist. 1992 Aug;41(8):448-56. German. PMID: 1524155. 20: Shevelev IA. Zritel'naia kora "po zakazu": dva rezhima raboty neĭronnykh mekhanizmov (problemnaia stat'ia) [The visual cortex "on command": 2 modes of operation of neuronal mechanisms (a topical article)]. Zh Evol Biokhim Fiziol. 1992 Mar-Apr;28(2):220-31. Russian. PMID: 1455949.

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