Fudosteine | Cleanal | SS-320A | CAS#13189-98-5 | MUC5AC Mucin Hypersecretion Inhibitor

MedKoo Cat#: 328809 | Name: Fudosteine

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fudosteine, also known as Cleanal and SS-320A, is a MUC5AC mucin hypersecretion inhibitor that is used as an expectorant in chronic bronchial inflammatory disorders.

Chemical Structure

Fudosteine

CAS#13189-98-5

Theoretical Analysis

MedKoo Cat#: 328809

Name: Fudosteine

CAS#: 13189-98-5

Chemical Formula: C6H13NO3S

Exact Mass: 179.0616

Molecular Weight: 179.23

Elemental Analysis: C, 40.21; H, 7.31; N, 7.81; O, 26.78; S, 17.89

Price and Availability

Size	Price	Availability
1g	USD 250.00	2 Weeks
5g	USD 450.00	2 Weeks
25g	USD 750.00	2 Weeks

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Related CAS #

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Synonym

Fudosteine; Fudostein; Cleanal; Spelear; S-(3-Hydroxypropyl)-L-cysteine; L-Cysteine, S-(3-hydroxypropyl)-; SS-320A; SS 320A; SS320A;

IUPAC/Chemical Name

S-(3-hydroxypropyl)-L-cysteine

InChi Key

KINWYTAUPKOPCQ-YFKPBYRVSA-N

InChi Code

InChI=1S/C6H13NO3S/c7-5(6(9)10)4-11-3-1-2-8/h5,8H,1-4,7H2,(H,9,10)/t5-/m0/s1

SMILES Code

N[C@@H](CSCCCO)C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 179.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gooty AR, Katreddi HR, S RR, Hunnur RK, Sharma HK, Masani NK. Simultaneous Determination of Genotoxic Impurities in Fudosteine Drugs by GC-MS. J Chromatogr Sci. 2016 Sep;54(8):1277-81. doi: 10.1093/chromsci/bmw070. Epub 2016 Jun 3. PubMed PMID: 27261527. 2: Ueno-Iio T, Shibakura M, Iio K, Tanimoto Y, Kanehiro A, Tanimoto M, Kataoka M. Effect of fudosteine, a cysteine derivative, on airway hyperresponsiveness, inflammation, and remodeling in a murine model of asthma. Life Sci. 2013 May 30;92(20-21):1015-23. doi: 10.1016/j.lfs.2013.03.022. Epub 2013 Apr 10. PubMed PMID: 23583570. 3: Fan PC, Ren J, Ma HP, Jing LL, Ma J, Jia ZP. Liquid Chromatography Tandem Mass/Mass Spectrometry for the Quantification of Fudosteine in Human Serum without Precolumn Derivatization. Iran J Pharm Res. 2014 Spring;13(2):441-7. PubMed PMID: 25237339; PubMed Central PMCID: PMC4157019. 4: Rhee CK, Kang CM, You MB, Yoon HK, Kim YK, Kim KH, Moon HS, Park SH, Song JS. Effect of fudosteine on mucin production. Eur Respir J. 2008 Nov;32(5):1195-202. doi: 10.1183/09031936.00018508. Epub 2008 Jun 25. PubMed PMID: 18579549. 5: Ding L, Yang J, Li RS, Zhou M, Shen JP, Zhang YD. [Pharmacokinetics of fudosteine in healthy volunteers]. Yao Xue Xue Bao. 2005 Oct;40(10):945-9. Chinese. PubMed PMID: 16408815. 6: Takahashi K, Iwase N, Ishikawa M, Mizuno H, Koda T, Kai H, Miyata T. [Effects of fudosteine, a new cysteine derivative, on airway secretion in rabbits and rats]. Nihon Yakurigaku Zasshi. 2000 Dec;116(6):371-8. Japanese. PubMed PMID: 11188505. 7: Takahashi K, Kai H, Mizuno H, Koda T, Miyata T. Effect of fudosteine, a new cysteine derivative, on mucociliary transport. J Pharm Pharmacol. 2001 Jun;53(6):911-4. PubMed PMID: 11428670. 8: Jiao HY, Zhang ZJ, Xu FG, Tian Y, Zhang BB, Chen Y. The pharmacokinetics of orally administered fudosteine in healthy Chinese volunteers. Eur J Drug Metab Pharmacokinet. 2006 Apr-Jun;31(2):65-71. PubMed PMID: 16898073. 9: Xu F, Zhang Z, Jiao H, Tian Y, Zhang B, Chen Y. Quantification of fudosteine in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry employing precolumn derivatization with 9-fluorenylmethyl chloroformate. J Mass Spectrom. 2006 May;41(5):685-92. PubMed PMID: 16598709. 10: Komatsu H, Yamaguchi S, Komorita N, Goto K, Takagi S, Ochi H, Okumoto T. Inhibition of endotoxin- and antigen-induced airway inflammation by fudosteine, a mucoactive agent. Pulm Pharmacol Ther. 2005;18(2):121-7. Epub 2004 Dec 20. PubMed PMID: 15649854.