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MedKoo Cat#: 328801 | Name: Imidazole Salicylate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Imidazole Salicylate, also known as ITF-182, is a non-steroidal anti-inflammatory drug with limited inhibitory effects on prostaglandin synthesis.

Chemical Structure

Imidazole Salicylate
Imidazole Salicylate
CAS#36364-49-5

Theoretical Analysis

MedKoo Cat#: 328801

Name: Imidazole Salicylate

CAS#: 36364-49-5

Chemical Formula: C10H10N2O3

Exact Mass: 206.0691

Molecular Weight: 206.20

Elemental Analysis: C, 58.25; H, 4.89; N, 13.59; O, 23.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Imidazole Salicylate; ITF-182; ITF 182; ITF182; Selezen; Salizolo
IUPAC/Chemical Name
1H-imidazole 2-hydroxybenzoate
InChi Key
XCHHJFVNQPPLJK-UHFFFAOYSA-N
InChi Code
InChI=1S/C7H6O3.C3H4N2/c8-6-4-2-1-3-5(6)7(9)10;1-2-5-3-4-1/h1-4,8H,(H,9,10);1-3H,(H,4,5)
SMILES Code
O=C(O)C1=CC=CC=C1O.C2=NC=CN2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 206.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Montrone F, Petrillo M, Ardizzone S, Scaricabarozzi I, Scotti A, Caruso I, Bianchi Porro G. Imidazole salicylate versus piroxicam in the treatment of arthrosis in elderly patients. A double-blind clinical and endoscopic trial. J Am Geriatr Soc. 1990 Sep;38(9):985-8. PubMed PMID: 2212452. 2: Salerno F, Lorenzano E, Maggi A, Badalamenti S, Minuz P, Degan M, Chinea B, Scotti A. Effects of imidazole-salicylate on renal function and the diuretic action of furosemide in cirrhotic patients with ascites. J Hepatol. 1993 Sep;19(2):279-84. PubMed PMID: 8301062. 3: Abdel-Haq B, Magagna A, Favilla S, Salvetti A. The interference of indomethacin and of imidazole salicylate on blood pressure control of essential hypertensive patients treated with atenolol. Preliminary report. Int J Clin Pharmacol Ther Toxicol. 1987 Nov;25(11):598-600. PubMed PMID: 3429061. 4: Schiassi M, Bianchini C, Restelli A, Zoni G. Tolerability profile of the antiinflammatory compound imidazole salicylate: a metanalysis of safety data in 1408 patients. Int J Tissue React. 1989;11(6):321-6. PubMed PMID: 2699882. 5: DiPerri T, Auteri A, Fumagalli M, Gandini R, Giordano A, Giordano M, Scaricabarozzi I, Vaiani G, Vatti M. Multicenter double-blind randomized clinical trial of imidazole salicylate versus ibuprofen in patients with rheumatoid arthritis. Int J Clin Pharmacol Ther Toxicol. 1987 Aug;25(8):443-7. PubMed PMID: 3308719. 6: Kaik B, Bauer K, Bröll H. Double-blind randomized clinical trial on imidazole salicylate vs ibuprofen in osteoarthritis. Int J Clin Pharmacol Ther Toxicol. 1991 May;29(5):173-7. PubMed PMID: 2071268. 7: Scaricabarozzi I, Chinea B, Scotti A. Imidazole salicylate in the treatment of osteoarthrosis and musculoskeletal trauma: a postmarketing survey. Clin Ther. 1988;10(2):229-36. PubMed PMID: 3273866. 8: Di Perri T, Auteri A, Caruso I, Corvetta A, Danieli G, Sarzi Puttini PC, Scaricabarozzi I. Multicenter double-blind randomized clinical trial of imidazole salicylate versus ibuprofen in patients with osteoarthrosis. Int J Clin Pharmacol Ther Toxicol. 1987 Sep;25(9):479-82. PubMed PMID: 3316058. 9: Zini R, Morin D, Acuto GC, Bianchini C, de Santis F, Tillement JP. Blood binding of selezen (imidazole salicylate) in man. Int J Clin Pharmacol Ther Toxicol. 1991 Jun;29(6):242-9. PubMed PMID: 1869346. 10: Lorenzano E, Badalamenti S, Scotti A, Scaricabarozzi I, Chinea B, Salerno F. Renal effects of imidazole-2-hydroxybenzoate in patients with compensated liver cirrhosis. Int J Clin Pharmacol Ther Toxicol. 1992 Jul;30(7):225-9. PubMed PMID: 1506125.