MedKoo Cat#: 326970 | Name: Hyzetimibe

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hyzetimibe, also known as HS-25, is a cholesterol absorption blocker potentially for the treatment of hypercholesterolemia.

Chemical Structure

Hyzetimibe
Hyzetimibe
CAS#1266548-75-7

Theoretical Analysis

MedKoo Cat#: 326970

Name: Hyzetimibe

CAS#: 1266548-75-7

Chemical Formula: C25H21F2NO3

Exact Mass: 421.1489

Molecular Weight: 421.44

Elemental Analysis: C, 71.25; H, 5.02; F, 9.02; N, 3.32; O, 11.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Hyzetimibe; HS 25; HS-25; HS25.
IUPAC/Chemical Name
(3R,4S)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-4-hydroxybut-2-enyl)-4-(4-hydroxyphenyl)-2-azetidinone
InChi Key
HEHHPZYUXSFAPV-GLGQCLCGSA-N
InChi Code
InChI=1S/C25H21F2NO3/c26-19-6-1-16(2-7-19)18(15-29)5-14-23-24(17-3-12-22(30)13-4-17)28(25(23)31)21-10-8-20(27)9-11-21/h1-13,23-24,29-30H,14-15H2/b18-5-/t23-,24-/m1/s1
SMILES Code
O=C1N(C2=CC=C(F)C=C2)[C@H](C3=CC=C(O)C=C3)[C@H]1C/C=C(C4=CC=C(F)C=C4)/CO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 421.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen J, Lou H, Jiang B, Shao R, Ruan Z, Wang J. Simultaneous determination of hyzetimibe and its main active metabolite in plasma by LC-MS/MS and its application in PK study. Bioanalysis. 2015;7(15):1857-67. doi: 10.4155/bio.15.114. PubMed PMID: 26295987. 2: Ruan Z, Jiang B, Chen J, Zhang X, Lou H, Xiang M, Shao Q, Wang J. Pharmacokinetics, pharmacodynamics, safety, and tolerability of hyzetimibe (HS-25) in healthy Chinese subjects. J Clin Pharmacol. 2014 Oct;54(10):1144-52. doi: 10.1002/jcph.310. Epub 2014 Apr 21. PubMed PMID: 24752831.