Levosalbutamol Hydrochloride | (R)-albuterol | CAS#50293-90-8 | CAS#34391-04-3 | β2-adrenergic receptor agonist

MedKoo Cat#: 328703 | Name: Levosalbutamol Hydrochloride

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Levosalbutamol Hydrochloride, also known as (R)-albuterol, is a β2-adrenergic receptor (β-AR) agonist used to treat asthma and chronic obstructive pulmonary disease.

Chemical Structure

Levosalbutamol Hydrochloride

CAS#50293-90-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 328703

Name: Levosalbutamol Hydrochloride

CAS#: 50293-90-8 (HCl)

Chemical Formula: C13H22ClNO3

Exact Mass:

Molecular Weight: 275.77

Elemental Analysis: C, 56.62; H, 8.04; Cl, 12.85; N, 5.08; O, 17.40

Price and Availability

Size	Price	Availability
10mg	USD 250.00	2 Weeks
25mg	USD 450.00	2 Weeks
50mg	USD 800.00	2 Weeks

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Related CAS #

50293-90-8(HCl) 34391-04-3(free base)

Synonym

Levosalbutamol Hydrochloride; Xopenex; (R)-albuterol; R-albuterol; R albuterol

IUPAC/Chemical Name

(R)-4-(2-(tert-butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol hydrochloride

InChi Key

OWNWYCOLFIFTLK-YDALLXLXSA-N

InChi Code

InChI=1S/C13H21NO3.ClH/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;/h4-6,12,14-17H,7-8H2,1-3H3;1H/t12-;/m0./s1

SMILES Code

O[C@@H](CNC(C)(C)C)C1=CC=C(O)C(CO)=C1.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# 34391-04-3 (Levosalbutamol) 50293-90-8 (Levosalbutamol Hydrochloride)

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Levalbuterol ((R)-Albuterol) hydrochloride is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol.

In vitro activity:

Treatment of transformed murine Club cells (MTCC) with (R)-albuterol (levalbuterol), but not with (S)- or a mixture of (R + S)- (racemic) albuterol, augmented mRNA expression of 11β-HSD1. These results demonstrate that levalbuterol augments expression of 11β-HSD1 in airway epithelial cells, reducing LPS-induced NF-κB transcriptional activity and pro-inflammatory cytokine production through the conversion of inactive 11-keto corticosteroids into the active 11-hydroxy form in this cell type. Reference: Front Endocrinol (Lausanne). 2015 Jan 12;5:236. https://pubmed.ncbi.nlm.nih.gov/25628603/

In vivo activity:

Mice (C57BL/6) sensitized and aerosol challenged with the allergen ovalbumin (OVA) or phosphate buffered saline (PBS) were treated with (R)-albuterol, (S)-albuterol or (R+S)-albuterol. In activated T cells, (R)-albuterol administration decreased levels of inflammatory cytokines and NF-kappaB activity. These studies suggest that (R)-albuterol decreases cytokine secretion and NF-kappaB activity in T cells. Reference: Respir Res. 2008 Jan 14;9(1):3. https://pubmed.ncbi.nlm.nih.gov/18194569/

	Solvent	mg/mL	mM
Solubility
	DMSO	20.0	72.52
	Ethanol	12.0	43.51
	PBS (pH 7.2)	3.0	10.88
	Water	100.0	362.62

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 275.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Flydal MI, Kråkenes TA, Tai MDS, Tran MPA, Teigen K, Martinez A. Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase. Biochimie. 2021 Apr;183:126-132. doi: 10.1016/j.biochi.2020.12.002. Epub 2020 Dec 10. PMID: 33309753. 2. Randall MJ, Kostin SF, Burgess EJ, Hoyt LR, Ather JL, Lundblad LK, Poynter ME. Anti-inflammatory effects of levalbuterol-induced 11β-hydroxysteroid dehydrogenase type 1 activity in airway epithelial cells. Front Endocrinol (Lausanne). 2015 Jan 12;5:236. doi: 10.3389/fendo.2014.00236. PMID: 25628603; PMCID: PMC4290686. 3. Ferrada MA, Gordon EL, Jen KY, He HZ, Lu X, Barone LM, Amirifeli S, Perkins DL, Finn PW. (R)-albuterol decreases immune responses: role of activated T cells. Respir Res. 2008 Jan 14;9(1):3. doi: 10.1186/1465-9921-9-3. PMID: 18194569; PMCID: PMC2253534.

In vitro protocol:

In vivo protocol:

1. Ferrada MA, Gordon EL, Jen KY, He HZ, Lu X, Barone LM, Amirifeli S, Perkins DL, Finn PW. (R)-albuterol decreases immune responses: role of activated T cells. Respir Res. 2008 Jan 14;9(1):3. doi: 10.1186/1465-9921-9-3. PMID: 18194569; PMCID: PMC2253534.

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