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MedKoo Cat#: 326941 | Name: Andolast

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Andolast, also known as CR-2039, an anti-allergic agent for the treatment of bronchial asthma, chronic obstructive pulmonary disease (COPD). Andolast acts at different cellular levels to inhibit immunoglobulin E synthesis. Andolast proved to be significantly more effective than placebo in improving airflow, and in controlling asthma symptoms both during day and night.

Chemical Structure

Andolast
Andolast
CAS#132640-22-3

Theoretical Analysis

MedKoo Cat#: 326941

Name: Andolast

CAS#: 132640-22-3

Chemical Formula: C15H11N9O

Exact Mass: 333.1087

Molecular Weight: 333.32

Elemental Analysis: C, 54.05; H, 3.33; N, 37.82; O, 4.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Andolast; CR-2039; CR 2039; CR2039.
IUPAC/Chemical Name
4-(1H-tetrazol-5-yl)-N-(4-(1H-tetrazol-5-yl)phenyl)benzamide
InChi Key
VXEBMQZDPONDFB-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H11N9O/c25-15(11-3-1-9(2-4-11)13-17-21-22-18-13)16-12-7-5-10(6-8-12)14-19-23-24-20-14/h1-8H,(H,16,25)(H,17,18,21,22)(H,19,20,23,24)
SMILES Code
O=C(NC1=CC=C(C2=NN=NN2)C=C1)C3=CC=C(C4=NN=NN4)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 333.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Malerba M, D Amato M, Radaeli A, Giacovelli G, Rovati L, Arshad SH, Holgate ST. Efficacy of Andolast in Mild to Moderate Asthma: A Randomized, Controlled, Double-Blind Multicenter Study (The Andast Trial). Curr Pharm Des. 2015;21(26):3835-43. PubMed PMID: 25845448. 2: Malerba M, Mennuni L, Piepoli T, Caselli G, Makovec F, Rovati LC, D' Amato M, Ferrari F. Andolast acts at different cellular levels to inhibit immunoglobulin E synthesis. Int J Immunopathol Pharmacol. 2009 Jan-Mar;22(1):85-94. PubMed PMID: 19309555. 3: Nardi A, Olesen SP. BK channel modulators: a comprehensive overview. Curr Med Chem. 2008;15(11):1126-46. Review. PubMed PMID: 18473808. 4: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Jun;29(5):359-73. PubMed PMID: 17805439. 5: Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Jun;25(5):387-408. PubMed PMID: 12851663. 6: Persiani S, D'Amato M, Makovec F, Arshad SH, Holgate ST, Rovati LC. Pharmacokinetics of andolast after administration of single escalating doses by inhalation in mild asthmatic patients. Biopharm Drug Dispos. 2001 Mar;22(2):73-81. PubMed PMID: 11745909.