MedKoo Cat#: 326936 | Name: Tosagestin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tosagestin, also known as Org-30659, is a progesterone receptor agonist potentially use in contraception. Daily oral administration of 0.060-0.240 mg of Org 30659 suppresses ovarian function to a level sufficient to inhibit ovulation.

Chemical Structure

Tosagestin
Tosagestin
CAS#110072-15-6

Theoretical Analysis

MedKoo Cat#: 326936

Name: Tosagestin

CAS#: 110072-15-6

Chemical Formula: C21H24O2

Exact Mass: 308.1776

Molecular Weight: 308.42

Elemental Analysis: C, 81.78; H, 7.84; O, 10.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Tosagestin; Org-30659; Org 30659; Org30659.
IUPAC/Chemical Name
17-Hydroxy-11-methylene-19-nor-17alpha-pregna-4,15-dien-20-yn-3-one
InChi Key
YJSTYQGZKJHXLN-LEZSPFLNSA-N
InChi Code
InChI=1S/C21H24O2/c1-4-21(23)10-9-18-17-7-5-14-11-15(22)6-8-16(14)19(17)13(2)12-20(18,21)3/h1,9-11,16-19,23H,2,5-8,12H2,3H3/t16-,17-,18-,19+,20-,21+/m0/s1
SMILES Code
C#C[C@@]([C@]1(C2)C)(O)C=C[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4([H])[C@@]3([H])C2=C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 308.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nieuwmeyer F, van der Voort Maarschalk K, Vromans H. Lactose contaminant as steroid degradation enhancer. Pharm Res. 2008 Nov;25(11):2666-73. doi: 10.1007/s11095-008-9687-z. Epub 2008 Aug 1. PubMed PMID: 18670867. 2: de Visser SJ, Uchida N, van Vliet-Daskalopoulou E, Fukazawa I, van Doorn MB, van den Heuvel MW, Machielsen CS, Uchida E, Cohen AF. Pharmacokinetic differences between Caucasian and Japanese subjects after single and multiple doses of a potential combined oral contraceptive (Org 30659 and EE). Contraception. 2003 Sep;68(3):195-202. PubMed PMID: 14561540. 3: Verhoeven CH, van Munster TT, Groothuis GM, Vos RM, Rietjens IM. Identification of the human P450 enzymes involved in the in vitro metabolism of the synthetic steroidal hormones Org 4060 and Org 30659. Xenobiotica. 2002 Feb;32(2):109-18. PubMed PMID: 11871398. 4: Obruca A, Korver T, Huber J, Killick SR, Landgren B, Struijs MJ. Ovarian function during and after treatment with the new progestagen Org 30659. Fertil Steril. 2001 Jul;76(1):108-15. PubMed PMID: 11438328. 5: Verhoeven CH, Gloudemans RH, Groothuis GM, Rietjens IM, Vos RM. Excretion balance and metabolism of the progestagen Org 30659 in healthy postmenopausal women. J Steroid Biochem Mol Biol. 2000 May;73(1-2):39-48. PubMed PMID: 10822023. 6: Verhoeven CH, Krebbers SF, Wagenaars GN, Booy CJ, Groothuis GM, Olinga P, Vos RM. In vitro and in vivo metabolism of the progestagen Org 30659 in several species. Drug Metab Dispos. 1998 Nov;26(11):1102-12. PubMed PMID: 9806953. 7: Schoonen WG, Joosten JW, Kloosterboer HJ. Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: II. T47D cell lines. J Steroid Biochem Mol Biol. 1995 Dec;55(3-4):439-44. PubMed PMID: 8541241. 8: Schoonen WG, Joosten JW, Kloosterboer HJ. Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: I. MCF-7 cell lines. J Steroid Biochem Mol Biol. 1995 Dec;55(3-4):423-37. PubMed PMID: 8541240. 9: van der Burg B, Kalkhoven E, Isbrücker L, de Laat SW. Effects of progestins on the proliferation of estrogen-dependent human breast cancer cells under growth factor-defined conditions. J Steroid Biochem Mol Biol. 1992 Jun;42(5):457-65. PubMed PMID: 1616875.