Synonym
Monoctanoin, Glyceryl 1-caprylate, Moctanin
IUPAC/Chemical Name
2,3-dihydroxypropyl octanoate
InChi Key
GHBFNMLVSPCDGN-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H22O4/c1-2-3-4-5-6-7-11(14)15-9-10(13)8-12/h10,12-13H,2-9H2,1H3
SMILES Code
CCCCCCCC(OCC(O)CO)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Glyceryl 1-monooctanoate is a broad-spectrum antimicrobial, suppresses the growth of pathogenic yeast (Candida albicans and Candida parapsilosis), as well as Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Klebsiella pneumoniae) bacteria.
|
Solvent |
mg/mL |
mM |
| Solubility |
| Soluble in CHCl3 |
100.0 |
458.10 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
218.29
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
1: Janssen D, Bommarito A, Lathrop J. A new technique for the rapid dissolution of retained ductal gallstones with monoctanoin in T-tube patients. Am Surg. 1992 Feb;58(2):141-5. PubMed PMID: 1550307.
2: Queralt Solari C, Quintana Martínez J, Insignares Ortiz E, Laguens Sahún G, Lozano Mantecón R. [Monoctanoin for the dissolution of biliary calculi. Report of a case]. Rev Esp Enferm Dig. 1991 Aug;80(2):133-5. Spanish. PubMed PMID: 1790079.
3: Smith BF. Dissolution of cholesterol gallstones in vitro. Gallstone matrix content and diameter, not cholesterol content, predict gallstone dissolution in monooctanoin. Gastroenterology. 1987 Jul;93(1):98-105. PubMed PMID: 3582920.
4: Tritapepe R, Di Padova C, Pozzoli M, Rovagnati P, Montorsi W. The treatment of retained biliary stones with monooctanoin: report of 16 patients. Am J Gastroenterol. 1984 Sep;79(9):710-4. PubMed PMID: 6475901.
5: Abate MA, Moore TL. Monooctanoin use for gallstone dissolution. Drug Intell Clin Pharm. 1985 Oct;19(10):708-13. Review. PubMed PMID: 3902430.
6: Teplick SK, Haskin PH. Monooctanoin perfusion for in vivo dissolution of biliary stones. A series of 11 patients. Radiology. 1984 Nov;153(2):379-83. PubMed PMID: 6484170.
7: Bogardus JB. Importance of viscosity in the dissolution rate of cholesterol in monooctanoin solutions. J Pharm Sci. 1984 Jul;73(7):906-10. PubMed PMID: 6470950.
8: Gadacz TR. The effect of monooctanoin on retained common duct stones. Surgery. 1981 May;89(5):527-31. PubMed PMID: 7221879.
9: Nijhawan S, Agarwal V, Sharma D, Rai RR. Evaluation of garlic oil as a contact dissolution agent for gallstones: comparison with monooctanoin. Trop Gastroenterol. 2000 Oct-Dec;21(4):177-9. PubMed PMID: 11194578.
10: Thistle JL, Carlson GL, Hofmann AF, LaRusso NF, MacCarty RL, Flynn GL, Higuchi WI, Babayan VK. Monooctanoin, a dissolution agent for retained cholesterol bile duct stones: physical properties and clinical application. Gastroenterology. 1980 May;78(5 Pt 1):1016-22. PubMed PMID: 7380174.
