Related CAS #
54533-86-7 (fumarate salt)
54533-85-6 (free)
Synonym
Nizofenone; Y-9179; Y 9179; Y9179; Ekonal
IUPAC/Chemical Name
(2-chlorophenyl)(2-(2-((diethylamino)methyl)-1H-imidazol-1-yl)-5-nitrophenyl)methanone
InChi Key
WZGBZLHGOVJDET-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H21ClN4O3/c1-3-24(4-2)14-20-23-11-12-25(20)19-10-9-15(26(28)29)13-17(19)21(27)16-7-5-6-8-18(16)22/h5-13H,3-4,14H2,1-2H3
SMILES Code
O=C(C1=CC=CC=C1Cl)C2=CC([N+]([O-])=O)=CC=C2N3C=CN=C3CN(CC)CC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
412.87
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Liu Y, Zhuang X, Gou L, Ling X, Tian X, Liu L, Zheng Y, Zhang L, Yin X. Protective effects of nizofenone administration on the cognitive impairments induced by chronic restraint stress in mice. Pharmacol Biochem Behav. 2013 Jan;103(3):474-80. doi: 10.1016/j.pbb.2012.09.009. Epub 2012 Sep 28. PubMed PMID: 23026061.
2: Nakamura T, Tsumagari T. [Effects of nizofenone on experimental arrhythmia in dogs]. Nihon Yakurigaku Zasshi. 1984 Nov;84(5):441-51. Japanese. PubMed PMID: 6097519.
3: Miura Y, Inui J, Nakamura T. [Effects of nizofenone on the action potential of guinea-pig papillary muscle and S-A node and dog Purkinje fibers]. Nihon Yakurigaku Zasshi. 1985 Mar;85(3):159-65. Japanese. PubMed PMID: 4007706.
4: Saito I, Asano T, Ochiai C, Takakura K, Tamura A, Sano K. A double-blind clinical evaluation of the effect of Nizofenone (Y-9179) on delayed ischemic neurological deficits following aneurysmal rupture. Neurol Res. 1983;5(4):29-47. PubMed PMID: 6149485.
5: Yasuda H, Izumi N, Nakanishi M, Maruyama Y. Brain protection against oxygen deficiency by nizofenone. Adv Exp Med Biol. 1988;222:403-10. PubMed PMID: 3364265.
6: Kotake H, Nawada T, Matsumoto T, Kitamura H, Kaneda T, Hasegawa J, Mashiba H. Chronotropic effect of nizofenone fumarate in rabbit sino-atrial node in vitro. Br J Pharmacol. 1988 Dec;95(4):1175-80. PubMed PMID: 3219485; PubMed Central PMCID: PMC1854257.
7: Ohta T, Kikuchi H, Hashi K, Kudo Y. Nizofenone administration in the acute stage following subarachnoid hemorrhage. Results of a multi-center controlled double-blind clinical study. J Neurosurg. 1986 Mar;64(3):420-6. PubMed PMID: 3512795.
8: Mizoi K, Olca M, Fujimoto S, Abiko H, Suzuki J. [An experimental study on the protective effect of nizofenone in cerebral ischemia]. No To Shinkei. 1984 Nov;36(11):1089-93. Japanese. PubMed PMID: 6525322.
9: Yasuda H, Nakajima A. Brain protection against ischemic injury by nizofenone. Cerebrovasc Brain Metab Rev. 1993 Winter;5(4):264-76. Review. PubMed PMID: 8110594.
10: Morimoto Y, Fukuda T, Tsumagari T. [Effects of nizofenone on ischemic cerebral edema in Mongolian gerbils]. No To Shinkei. 1984 Oct;36(10):983-8. Japanese. PubMed PMID: 6518129.
