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MedKoo Cat#: 328504 | Name: Oxitropium Bromide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Oxitropium Bromide, also known as BA-253 and Oxivent, is a muscarinic cholinergic receptor antagonist used to treat asthma and chronic obstructive pulmonary.

Chemical Structure

Oxitropium Bromide
Oxitropium Bromide
CAS#30286-75-0

Theoretical Analysis

MedKoo Cat#: 328504

Name: Oxitropium Bromide

CAS#: 30286-75-0

Chemical Formula: C19H26BrNO4

Exact Mass:

Molecular Weight: 412.32

Elemental Analysis: C, 55.35; H, 6.36; Br, 19.38; N, 3.40; O, 15.52

Price and Availability

This product was removed for the commercial reasons.
Related CAS #
No Data
Synonym
Oxitropium Bromide; BA-253; BA 253; BA253; Oxivent; Tersigan
IUPAC/Chemical Name
(1R,2R,4S,5S,7s,9r)-9-ethyl-7-((3-hydroxy-2-phenylpropanoyl)oxy)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium
InChi Key
NVOYVOBDTVTBDX-PBXANPGYSA-N
InChi Code
InChI=1S/C19H26NO4/c1-3-20(2)15-9-13(10-16(20)18-17(15)24-18)23-19(22)14(11-21)12-7-5-4-6-8-12/h4-8,13-18,21H,3,9-11H2,1-2H3/q+1/t13-,14?,15-,16+,17-,18+,20+
SMILES Code
[H][C@]12C[C@H](OC(C(C3=CC=CC=C3)CO)=O)C[C@]([C@@H]4[C@H]1O4)([N@@+]2(CC)C)[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 412.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shindoh C, Shishido R, Sasaki K, Miura M. Effects of inhalation or incubation of oxitropium bromide on diaphragm muscle contractility in mice. Allergol Int. 2011 Sep;60(3):365-72. doi: 10.2332/allergolint.10-OA-0266. Epub 2011 May 25. PubMed PMID: 21593578. 2: Cazzola M, Di Perna F, Califano C, Vinciguerra A, D'Amato M. Incremental benefit of adding oxitropium bromide to formoterol in patients with stable COPD. Pulm Pharmacol Ther. 1999;12(4):267-71. PubMed PMID: 10501652. 3: Skoko Ž, Zamir S, Naumov P, Bernstein J. The thermosalient phenomenon. "Jumping crystals" and crystal chemistry of the anticholinergic agent oxitropium bromide. J Am Chem Soc. 2010 Oct 13;132(40):14191-202. doi: 10.1021/ja105508b. PubMed PMID: 20860383. 4: Cazzola M, Di Perna F, Noschese P, Vinciguerra A, Calderaro F, Girbino G, Matera MG. Effects of formoterol, salmeterol or oxitropium bromide on airway responses to salbutamol in COPD. Eur Respir J. 1998 Jun;11(6):1337-41. PubMed PMID: 9657576. 5: Kneubühler HR, Kyd K, Benoit RC, Scherrer M. [The new anticholinergic bronchospasmolytic oxitropium bromide. Is long lasting protective effect through the night]. Schweiz Med Wochenschr. 1980 May 24;110(21):812-6. German. PubMed PMID: 7394499. 6: Cazzola M, Matera MG, Di Perna E, Califano C, D'Amato M, Mazzarella G. Influence of higher than conventional doses of oxitropium bromide on formoterol-induced bronchodilation in COPD. Respir Med. 1999 Dec;93(12):909-11. PubMed PMID: 10653054. 7: Bellia V, Foresi A, Bianco S, Grassi V, Olivieri D, Bensi G, Volonté M; BREATH Italian Study Group. Efficacy and safety of oxitropium bromide, theophylline and their combination in COPD patients: a double-blind, randomized, multicentre study (BREATH Trial). Respir Med. 2002 Nov;96(11):881-9. PubMed PMID: 12418585. 8: Cazzola M, Matera MG, Di Perna F, Calderaro F, Califano C, Vinciguerra A. A comparison of bronchodilating effects of salmeterol and oxitropium bromide in stable chronic obstructive pulmonary disease. Respir Med. 1998 Feb;92(2):354-7. PubMed PMID: 9616538. 9: Bryant DH, Rogers P. Oxitropium bromide: an acute dose response study of a new anticholinergic drug in combination with fenoterol in asthma and chronic bronchitis. Pulm Pharmacol. 1990;3(2):55-8. PubMed PMID: 2135210. 10: Fujimura M, Kamio Y, Matsuda T, Hashimoto T. Bronchodilator effects of oxitropium bromide, fenoterol, and their combination in normal subjects. Clin Auton Res. 1993 Feb;3(1):31-5. PubMed PMID: 8477178.