Parecoxib sodium | Dynastat | SC-69124A | CAS#198470-85-8 | CAS#198470-84-7 | Cyclooxygenase-2 Inhibitor

MedKoo Cat#: 329414 | Name: Parecoxib sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Parecoxib, also known as SC-69124A and Dynastat, is a cyclooxygenase-2 inhibitor used for the short-term treatment of postoperative pain in adults. Parecoxib is a water-soluble and injectable prodrug of valdecoxib. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). Unlike ketorolac, parecoxib has no effect on platelet function and therefore does not promote bleeding during or after surgery. In addition, ketorolac has a much higher gastrointestinal toxicity profile compared to most other nonsteroidal antiinflammatory drugs (NSAIDs) including ibuprofen and naprosyn.

Chemical Structure

Parecoxib sodium

CAS#198470-85-8 (sodium)

Theoretical Analysis

MedKoo Cat#: 329414

Name: Parecoxib sodium

CAS#: 198470-85-8 (sodium)

Chemical Formula: C19H17N2NaO4S

Exact Mass: 0.0000

Molecular Weight: 392.40

Elemental Analysis: C, 58.16; H, 4.37; N, 7.14; Na, 5.86; O, 16.31; S, 8.17

Price and Availability

Size	Price	Availability
200mg	USD 250.00	2 Weeks
500mg	USD 450.00	2 Weeks
1g	USD 650.00	2 Weeks
2g	USD 1,050.00	2 Weeks
5g	USD 1,950.00	2 Weeks
10g	USD 2,850.00	2 Weeks
20g	USD 3,650.00	2 Weeks

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Related CAS #

198470-84-7 (free base); 198470-85-8 (sodium)

Synonym

Parecoxib sodium; SC-69124A; SC 69124A; SC69124A; Dynastat

IUPAC/Chemical Name

sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide

InChi Key

HQPVVKXJNZEAFW-UHFFFAOYSA-M

InChi Code

InChI=1S/C19H18N2O4S.Na/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;/h4-12H,3H2,1-2H3,(H,21,22);/q;+1/p-1

SMILES Code

CCC([N-]S(=O)(C1=CC=C(C2=C(C)ON=C2C3=CC=CC=C3)C=C1)=O)=O.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS#: 198470-84-7 (Parecoxib ) 198470-85-8 (Parecoxib Sodium) As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States.

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Parecoxib Sodium (SC 69124A) is a highly selective and orally active COX-2 inhibitor, the prodrug of Valdecoxib (HY-15762).

In vitro activity:

Parecoxib-treated H9c2 cells stimulated with LPS were tested for viability using the Cell Counting Kit-8 assay. The data showed that parecoxib significantly and dose-dependently reduced the inflammatory responses of LPS-treated H9c2 cells. Parecoxib also significantly and dose-dependently increased the proliferation and inhibited the apoptosis of LPS-treated H9c2 cells. In addition, parecoxib significantly suppressed the activation of the MAPK (p38, JNK and ERK) signaling pathway. Reference: Exp Ther Med. 2023 Feb 16;25(4):150. https://pubmed.ncbi.nlm.nih.gov/36911374/

In vivo activity:

Adult male ICR mice were randomly divided into four groups: the control group and three parecoxib groups. Mice received normal saline or parecoxib (2.5, 5.0 or 10 mg/kg) intraperitoneal injection once a day for 21 days, respectively. Chronic parecoxib exerted an anxiolytic-like effect in the plus-maze test test, and enhanced memory performance in the novel object recognition and Y maze tests. Western blot analysis showed that chronic parecoxib down-regulated synaptophysin levels in the amygdala and up-regulated synaptophysin levels in the hippocampus. ELISA assay showed that chronic parecoxib inhibited PGE2 in the hippocampus but not amygdala. Reference: BMC Anesthesiol. 2017 Nov 13;17(1):152. https://pubmed.ncbi.nlm.nih.gov/29132299/

	Solvent	mg/mL	mM
Solubility
	DMF	10.0	25.48
	DMSO	64.3	163.95
	Ethanol	3.0	7.65
	PBS (pH 7.2)	5.0	12.74
	Water	56.3	143.35

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 392.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Qian X, Xiong S, Chen Q, Zhang J, Xie J. Parecoxib attenuates inflammation injury in septic H9c2 cells by regulating the MAPK signaling pathway. Exp Ther Med. 2023 Feb 16;25(4):150. doi: 10.3892/etm.2023.11850. PMID: 36911374; PMCID: PMC9995842. 2. Li X, Zhou JX, Qu YD, Kuang X. Сyclooxygenase-2 Inhibitor Parecoxib Reduces LPS-Induced Activation of BV2 Microglia Cells. Bull Exp Biol Med. 2022 Dec;174(2):210-215. doi: 10.1007/s10517-023-05675-8. Epub 2023 Jan 5. PMID: 36600038. 3. Guo J, Yang Y. Parecoxib sodium alleviates ischemia reperfusion-induced pulmonary injury via inhibiting ERK/NF-κB and further activating the HIF-1α pathway. Immun Inflamm Dis. 2022 Sep;10(9):e684. doi: 10.1002/iid3.684. PMID: 36039646; PMCID: PMC9382860. 4. Wang B, Jin X, Kuang X, Tian S. Chronic administration of parecoxib exerts anxiolytic-like and memory enhancing effects and modulates synaptophysin expression in mice. BMC Anesthesiol. 2017 Nov 13;17(1):152. doi: 10.1186/s12871-017-0443-y. PMID: 29132299; PMCID: PMC5684753.

In vitro protocol:

In vivo protocol:

1. Guo J, Yang Y. Parecoxib sodium alleviates ischemia reperfusion-induced pulmonary injury via inhibiting ERK/NF-κB and further activating the HIF-1α pathway. Immun Inflamm Dis. 2022 Sep;10(9):e684. doi: 10.1002/iid3.684. PMID: 36039646; PMCID: PMC9382860. 2. Wang B, Jin X, Kuang X, Tian S. Chronic administration of parecoxib exerts anxiolytic-like and memory enhancing effects and modulates synaptophysin expression in mice. BMC Anesthesiol. 2017 Nov 13;17(1):152. doi: 10.1186/s12871-017-0443-y. PMID: 29132299; PMCID: PMC5684753.

1: Cao L, Zhang L, Chen B, Yan L, Shi X, Tian L. Application of multimodal standardized analgesia under the concept of enhanced recovery after surgery in laparoscopic radical colorectal cancer surgery. Front Oncol. 2024 May 21;14:1381809. doi: 10.3389/fonc.2024.1381809. PMID: 38835370; PMCID: PMC11148287. 2: Zhang X, Zhang C, Zheng X, Xu A, Chen P. The Laparoscopic Right-lower Quadrant Approach for the Treatment of Right-sided Colon Cancer Offers Advantages Such as Shorter Surgical Time and Less Blood Loss. Altern Ther Health Med. 2024 May 17:AT10266. Epub ahead of print. PMID: 38758145. 3: Li J, Chen H, Zuo J, Zhang X. Effect of fascia iliaca compartment block combined with ropivacaine on post-operative outcomes in elderly patients undergoing hip fracture repair. Pak J Med Sci. 2024 Mar-Apr;40(4):757-762. doi: 10.12669/pjms.40.4.8283. PMID: 38544994; PMCID: PMC10963986. 4: Wu R, Liu R, Zhang Y, Li X. [Parecoxib sodium down-regulates CXCL8-CXCR1/2 to improve inflammatory microenvironment and promote patient recovery following laparoscopic radical resection of rectal cancer]. Nan Fang Yi Ke Da Xue Xue Bao. 2024 Feb 20;44(2):363-369. Chinese. doi: 10.12122/j.issn.1673-4254.2024.02.19. PMID: 38501422; PMCID: PMC10954531. 5: Huang D, Zhang Z, Jian J, Jiang X, Gao J, Yang M, Ding X. Parecoxib sodium attenuates acute lung injury following burns by regulating M1/M2 macrophage polarization through the TLR4/NF-κB pathway. Eur J Pharmacol. 2024 Apr 5;968:176407. doi: 10.1016/j.ejphar.2024.176407. Epub 2024 Feb 15. PMID: 38365106. 6: Methods In Medicine CAM. Retracted: Effect of Parecoxib Sodium Combined with Dexmedetomidine on Analgesia and Postoperative Pain of Patients Undergoing Hysteromyomectomy. Comput Math Methods Med. 2023 Dec 13;2023:9786509. doi: 10.1155/2023/9786509. PMID: 38124957; PMCID: PMC10732949. 7: Ai HY, Cheng MY. The effect of parecoxib sodium combined with perioperative psychological care on postoperative pain in elderly patients with hip fractures. Eur Rev Med Pharmacol Sci. 2023 Aug;27(16):7749-7755. doi: 10.26355/eurrev_202308_33429. PMID: 37667953. 8: Wang X, Dong W, Song Z, Wang H, You J, Zheng R, Xu Y, Zhang X, Guo J, Tian L, Fan F. Comparing the Effectiveness of Betamethasone and Triamcinolone Acetonide in Multimodal Cocktail Intercostal Injection for Chest Pain After Harvesting Costal Cartilage: A Prospective, Double-Blind, Randomized Controlled Study. Aesthetic Plast Surg. 2024 Mar;48(6):1111-1117. doi: 10.1007/s00266-023-03461-5. Epub 2023 Jul 12. PMID: 37438661. 9: Qi M, Xiao W, Yang S, Wang S, Zhou L, Wan A, Feng S, Yao D, Wang C, Wang T. Pre-incisional Preventive Precise Multimodal Analgesia May Enhance the Rehabilitation Process of Acute Postoperative Pain Following Total Laparoscopic Hysterectomy: A Randomized Controlled Trial. Pain Physician. 2023 May;26(3):E123-E131. PMID: 37192230. 10: Wang JH, Liu T, Bai Y, Chen YQ, Cui YH, Gao XY, Guo JR. The effect of parecoxib sodium on postoperative delirium in elderly patients with hip arthroplasty. Front Pharmacol. 2023 Mar 20;14:947982. doi: 10.3389/fphar.2023.947982. PMID: 37025488; PMCID: PMC10072322. 11: Zhang Z, Fan D, Zheng L, Li H, Zhang X, Yang X. Comparison of pharmacokinetic profiles in hypoalbuminemia and healthy rats after parecoxib sodium injection by LC-MS/MS. Bioanalysis. 2023 Feb;15(4):231-243. doi: 10.4155/bio-2022-0197. Epub 2023 Apr 6. PMID: 37021772. 12: Xu S, Li X, Li W, Ma N, Ma H, Cui J, You X, Chen X. Sufentanil combined with parecoxib sodium inhibits proliferation and metastasis of HER2-positive breast cancer cells and regulates epithelial-mesenchymal transition. Clin Exp Metastasis. 2023 Apr;40(2):149-160. doi: 10.1007/s10585-023-10199-6. Epub 2023 Feb 18. PMID: 36807216. 13: Chen C, Zhang Z, Lin M, Wang Z, Liu H, Meng H, Wang J, Chen M, Xiang S, Qiu Y, Liu H. Acupressure versus parecoxib sodium in acute renal colic: A prospective cohort study. Front Med (Lausanne). 2023 Jan 9;9:968433. doi: 10.3389/fmed.2022.968433. PMID: 36698807; PMCID: PMC9868725. 14: Wang F, Peng P, Zheng Y, Cheng S, Chen Y. Effect of Acupuncture on Postoperative Pain in Patients after Laparoscopic Cholecystectomy: A Randomized Clinical Trial. Evid Based Complement Alternat Med. 2023 Jan 13;2023:3697223. doi: 10.1155/2023/3697223. PMID: 36686975; PMCID: PMC9859706. 15: Zhang N, Li Y, Feng Z. Inhibition effect of choline and parecoxib sodium on chronic constriction nerve injury-induced neuropathic pain in rats. BMC Anesthesiol. 2023 Jan 13;23(1):22. doi: 10.1186/s12871-022-01913-0. PMID: 36639747; PMCID: PMC9837992. 16: Wang X, Chen Y, Zhao Y, Wang Z, Zhao L, Hou J, Liu F. Effect of Parecoxib Sodium Combined with Dexmedetomidine on Analgesia and Postoperative Pain of Patients Undergoing Hysteromyomectomy. Comput Math Methods Med. 2022 Oct 14;2022:5123933. doi: 10.1155/2022/5123933. Retraction in: Comput Math Methods Med. 2023 Dec 13;2023:9786509. doi: 10.1155/2023/9786509. PMID: 36277001; PMCID: PMC9586765. 17: Hong C, Xie HY, Ge WK, Yu M, Lin SN, Liu CJ. The efficacy of parecoxib in improving pain after total knee or total hip arthroplasty: Systematic review and meta-analysis. Medicine (Baltimore). 2022 Sep 23;101(38):e30748. doi: 10.1097/MD.0000000000030748. PMID: 36197263; PMCID: PMC9509050. 18: Hao Y, Yin G, Wang X, Jiang Z, Zhang G, Feng Z, Sun Q. Application of ICH Guidelines for the Assessment and Control of Elemental Impurities in Parecoxib Sodium by Graphite-Digestion and ICP-MS. Int J Anal Chem. 2022 Aug 24;2022:9299416. doi: 10.1155/2022/9299416. PMID: 36060533; PMCID: PMC9433241. 19: Guo J, Yang Y. Parecoxib sodium alleviates ischemia reperfusion-induced pulmonary injury via inhibiting ERK/NF-κB and further activating the HIF-1α pathway. Immun Inflamm Dis. 2022 Sep;10(9):e684. doi: 10.1002/iid3.684. PMID: 36039646; PMCID: PMC9382860. 20: Deng L, Tan L. Effects of Parecoxib Sodium Application Combined with Enhanced Recovery After Surgery Nursing on Inflammatory Factors and Knee Joint Function in Elderly Patients After Total Knee Arthroplasty. Front Surg. 2022 Jun 8;9:902351. doi: 10.3389/fsurg.2022.902351. PMID: 36034381; PMCID: PMC9407036.

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Description:

Chemical Structure

Theoretical Analysis

Price and Availability

Preparing Stock Solutions

View History

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