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MedKoo Cat#: 526876 | Name: AM-2099

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AM-2099 is a potent and selective NaV1.7 Inhibitor (hNav1.7 IC50 = 0.16 uM; hNav1.5 IC50 > 30 uM; Papp = 31 x 10 (-6)cm/s; Rat IV CL (b/h/kg) \= 0.54; cLogD = 2.1). AM-2099 demonstrated a favorable pharmacokinetic profile in rat and dog and demonstrated dose-dependent reduction of histamine-induced scratching bouts in a mouse behavioral model following oral dosing.

Chemical Structure

AM-2099
AM-2099
CAS#1443373-17-8

Theoretical Analysis

MedKoo Cat#: 526876

Name: AM-2099

CAS#: 1443373-17-8

Chemical Formula: C19H13F3N4O3S2

Exact Mass: 466.0381

Molecular Weight: 466.45

Elemental Analysis: C, 48.92; H, 2.81; F, 12.22; N, 12.01; O, 10.29; S, 13.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AM-2099; AM2099; AM 2099.
IUPAC/Chemical Name
4-(2-methoxy-4-(trifluoromethyl)phenyl)-N-(thiazol-2-yl)quinazoline-7-sulfonamide
InChi Key
VSUDRCZPHWUXEW-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H13F3N4O3S2/c1-29-16-8-11(19(20,21)22)2-4-14(16)17-13-5-3-12(9-15(13)24-10-25-17)31(27,28)26-18-23-6-7-30-18/h2-10H,1H3,(H,23,26)
SMILES Code
O=S(C1=CC=C2C(N=CN=C2C3=C(OC)C=C(C(F)(F)F)C=C3)=C1)(NC4=NC=CS4)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 466.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement Isaac E. Marx, Thomas A. Dineen, Jessica Able, Christiane Bode, Howard Bregman, Margaret Chu-Moyer, Erin F. DiMauro, Bingfan Du, Robert S. Foti, Robert T. Fremeau Jr., Hua Gao, Hakan Gunaydin, Brian E. Hall, Liyue Huang, Thomas Kornecook, Charles R. Kreiman, Daniel S. La, Joseph Ligutti, Min-Hwa Jasmine Lin, Dong Liu, Jeff S. McDermott, Bryan D. Moyer, Emily A. Peterson, Jonathan T. Roberts, Paul Rose, Jean Wang, Beth D. Youngblood, Violeta Yu, and Matthew M. Weiss Publication Date (Web): September 21, 2016 (Letter) DOI: 10.1021/acsmedchemlett.6b00243