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MedKoo Cat#: 328408 | Name: Phenelzine Sulfate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Phenelzine Sulfate, also known as Nardil and W-1544, is a monoamine oxidase inhibitor used to treat depression, phobic disorders, and panic.

Chemical Structure

Phenelzine Sulfate
Phenelzine Sulfate
CAS#156-51-4 (sulfate)

Theoretical Analysis

MedKoo Cat#: 328408

Name: Phenelzine Sulfate

CAS#: 156-51-4 (sulfate)

Chemical Formula: C8H14N2O4S

Exact Mass: 0.0000

Molecular Weight: 234.27

Elemental Analysis: C, 41.02; H, 6.02; N, 11.96; O, 27.32; S, 13.69

Price and Availability

Size Price Availability Quantity
250mg USD 250.00 Ready to ship
500mg USD 400.00 Ready to ship
1g USD 650.00 2 Weeks
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Related CAS #
156-51-4 (Sulfate) 51-71-8(free base)
Synonym
Phenelzine Sulfate; W1544; W-1544; W 1544; Nardil
IUPAC/Chemical Name
phenethylhydrazine sulfate
InChi Key
RXBKMJIPNDOHFR-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H12N2.H2O4S/c9-10-7-6-8-4-2-1-3-5-8;1-5(2,3)4/h1-5,10H,6-7,9H2;(H2,1,2,3,4)
SMILES Code
NNCCC1=CC=CC=C1.O=S(O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# 156-51-4(Phenelzine Sulfate) 51-71-8(Phenelzine)
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Phenelzine Sulfate, also known as Nardil and W-1544, is a monoamine oxidase inhibitor.
In vitro activity:
This study developed an in vitro assay that allows the investigation of the oxidative damage caused by peroxynitrite in the intravascular compartment. This assay correlates the damage with the rate of formation of protein carbonyl groups, 3-nitrotyrosine (3-NT) and thiobarbituric acid reactive substances. Using this assay, this study evaluated the ability of phenelzine, a scavenger of reactive aldehydes, to antagonize the effects of peroxynitrite. Herein, this study showed that phenelzine significantly decreased the lipid peroxidative damage caused by peroxynitirite in blood plasma and platelets. Reference: Arch Physiol Biochem. 2018 Dec;124(5):418-423. https://pubmed.ncbi.nlm.nih.gov/29256275/
In vivo activity:
In mice, intraperitoneal injection of phenelzine immediately after severe thoracic compression, and thereafter once daily for 6 weeks, improved hind limb function, reduced astrogliosis and promoted axonal regrowth/sprouting at 4 and 5 weeks after spinal cord injury compared to vehicle control-treated mice. Phenelzine application upregulated L1 expression in the spinal cord and stimulated the cognate L1-mediated intracellular signaling cascades in the spinal cord tissue. Phenelzine-treated mice showed decreased levels of pro-inflammatory cytokines, such as interleukin-1β, interleukin-6, and tumor necrosis factor-α in the injured spinal cord during the acute phase of inflammation. Reference: Restor Neurol Neurosci. 2018;36(4):469-483. https://pubmed.ncbi.nlm.nih.gov/29889084/
Solvent mg/mL mM comments
Solubility
DMSO 47.0 200.00
Ethanol 2.0 8.54
Water 47.0 200.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 234.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Mustafa AG, Al-Shboul O, Alfaqih MA, Al-Qudah MA, Al-Dwairi AN. Phenelzine reduces the oxidative damage induced by peroxynitrite in plasma lipids and proteins. Arch Physiol Biochem. 2018 Dec;124(5):418-423. doi: 10.1080/13813455.2017.1415939. Epub 2017 Dec 19. PMID: 29256275. 2. Cebak JE, Singh IN, Hill RL, Wang JA, Hall ED. Phenelzine Protects Brain Mitochondrial Function In Vitro and In Vivo following Traumatic Brain Injury by Scavenging the Reactive Carbonyls 4-Hydroxynonenal and Acrolein Leading to Cortical Histological Neuroprotection. J Neurotrauma. 2017 Apr 1;34(7):1302-1317. doi: 10.1089/neu.2016.4624. Epub 2016 Dec 2. PMID: 27750484; PMCID: PMC5385448. 3. Li R, Sahu S, Schachner M. Phenelzine, a small organic compound mimicking the functions of cell adhesion molecule L1, promotes functional recovery after mouse spinal cord injury. Restor Neurol Neurosci. 2018;36(4):469-483. doi: 10.3233/RNN-170808. PMID: 29889084. 4. Potter LE, Doolen S, Mifflin K, Tenorio G, Baker G, Taylor BK, Kerr BJ. Antinociceptive Effects of the Antidepressant Phenelzine are Mediated by Context-Dependent Inhibition of Neuronal Responses in the Dorsal Horn. Neuroscience. 2018 Jul 15;383:205-215. doi: 10.1016/j.neuroscience.2018.04.047. Epub 2018 May 9. PMID: 29752984; PMCID: PMC6398164.
In vitro protocol:
1. Mustafa AG, Al-Shboul O, Alfaqih MA, Al-Qudah MA, Al-Dwairi AN. Phenelzine reduces the oxidative damage induced by peroxynitrite in plasma lipids and proteins. Arch Physiol Biochem. 2018 Dec;124(5):418-423. doi: 10.1080/13813455.2017.1415939. Epub 2017 Dec 19. PMID: 29256275. 2. Cebak JE, Singh IN, Hill RL, Wang JA, Hall ED. Phenelzine Protects Brain Mitochondrial Function In Vitro and In Vivo following Traumatic Brain Injury by Scavenging the Reactive Carbonyls 4-Hydroxynonenal and Acrolein Leading to Cortical Histological Neuroprotection. J Neurotrauma. 2017 Apr 1;34(7):1302-1317. doi: 10.1089/neu.2016.4624. Epub 2016 Dec 2. PMID: 27750484; PMCID: PMC5385448.
In vivo protocol:
1. Li R, Sahu S, Schachner M. Phenelzine, a small organic compound mimicking the functions of cell adhesion molecule L1, promotes functional recovery after mouse spinal cord injury. Restor Neurol Neurosci. 2018;36(4):469-483. doi: 10.3233/RNN-170808. PMID: 29889084. 2. Potter LE, Doolen S, Mifflin K, Tenorio G, Baker G, Taylor BK, Kerr BJ. Antinociceptive Effects of the Antidepressant Phenelzine are Mediated by Context-Dependent Inhibition of Neuronal Responses in the Dorsal Horn. Neuroscience. 2018 Jul 15;383:205-215. doi: 10.1016/j.neuroscience.2018.04.047. Epub 2018 May 9. PMID: 29752984; PMCID: PMC6398164.
1: Qiu Y, Huang Y, Ma X. [Effect of phenelzine on the proliferation, apoptosis and histone methylation and acetylation of Molt-4 cells]. Zhonghua Xue Ye Xue Za Zhi. 2016 Feb;37(2):144-8. doi: 10.3760/cma.j.issn.0253-2727.2016.02.012. Chinese. PubMed PMID: 27014985. 2: Yan HJ, Zhou SY, Li Y, Zhang H, Deng CY, Qi H, Li FR. The effects of LSD1 inhibition on self-renewal and differentiation of human induced pluripotent stem cells. Exp Cell Res. 2016 Jan 15;340(2):227-37. doi: 10.1016/j.yexcr.2015.12.015. Epub 2015 Dec 31. PubMed PMID: 26748182. 3: Mateo-Carrasco H, Muñoz-Aguilera EM, García-Torrecillas JM, Abu Al-Robb H. Serotonin syndrome probably triggered by a morphine-phenelzine interaction. Pharmacotherapy. 2015 Jun;35(6):e102-5. doi: 10.1002/phar.1581. Epub 2015 Apr 22. PubMed PMID: 25903219. 4: Carpéné C, Gomez-Zorita S, Gupta R, Grès S, Rancoule C, Cadoudal T, Mercader J, Gomez A, Bertrand C, Iffiu-Soltész Z. Combination of low dose of the anti-adipogenic agents resveratrol and phenelzine in drinking water is not sufficient to prevent obesity in very-high-fat diet-fed mice. Eur J Nutr. 2014 Dec;53(8):1625-35. doi: 10.1007/s00394-014-0668-1. Epub 2014 Feb 15. PubMed PMID: 24531732. 5: Matveychuk D, Nunes E, Ullah N, Aldawsari FS, Velázquez-Martínez CA, Baker GB. Elevation of rat brain tyrosine levels by phenelzine is mediated by its active metabolite β-phenylethylidenehydrazine. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Aug 4;53:67-73. doi: 10.1016/j.pnpbp.2014.02.011. Epub 2014 Mar 6. PubMed PMID: 24607770. 6: CONDELOPEZ V, RUBIOSANCHEZ JL. [OUR EXPERIENCE IN PSYCHOSOMATIC PATHOLOGY WITH PHENELZINE SULFATE]. Rev Clin Esp. 1964 May 31;93:256-63. Spanish. PubMed PMID: 14155875. 7: Ravaris CL, Nies A, Robinson DS, Ives JO, Lamborn KR, Korson L. A multiple-dose, controlled study of phenelzine in depression-anxiety states. Arch Gen Psychiatry. 1976 Mar;33(3):347-50. PubMed PMID: 769725. 8: LEVY L, LOHRENZ J. The use of phenelzine sulfate (nardil) in depression. Can Med Assoc J. 1960 May 14;82:1031-2. PubMed PMID: 14416413; PubMed Central PMCID: PMC1938344. 9: Prusevich P, Kalin JH, Ming SA, Basso M, Givens J, Li X, Hu J, Taylor MS, Cieniewicz AM, Hsiao PY, Huang R, Roberson H, Adejola N, Avery LB, Casero RA Jr, Taverna SD, Qian J, Tackett AJ, Ratan RR, McDonald OG, Feinberg AP, Cole PA. A selective phenelzine analogue inhibitor of histone demethylase LSD1. ACS Chem Biol. 2014 Jun 20;9(6):1284-93. doi: 10.1021/cb500018s. Epub 2014 Apr 7. PubMed PMID: 24707965; PubMed Central PMCID: PMC4076021. 10: Blanco C, Heimberg RG, Schneier FR, Fresco DM, Chen H, Turk CL, Vermes D, Erwin BA, Schmidt AB, Juster HR, Campeas R, Liebowitz MR. A placebo-controlled trial of phenelzine, cognitive behavioral group therapy, and their combination for social anxiety disorder. Arch Gen Psychiatry. 2010 Mar;67(3):286-95. doi: 10.1001/archgenpsychiatry.2010.11. PubMed PMID: 20194829; PubMed Central PMCID: PMC2856667.