Synonym
Pinacidil; P-1134; P 1134; P1134; S-1230; S 1230; S1230
IUPAC/Chemical Name
(Z)-2-cyano-1-(3,3-dimethylbutan-2-yl)-3-(pyridin-4-yl)guanidine
InChi Key
IVVNZDGDKPTYHK-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H19N5/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11/h5-8,10H,1-4H3,(H2,15,16,17,18)
SMILES Code
CC(C)(C)C(N/C(NC1=CC=NC=C1)=N/C#N)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
245.33
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Friedel HA, Brogden RN. Pinacidil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the treatment of hypertension. Drugs. 1990 Jun;39(6):929-67. Review. PubMed PMID: 2196168.
2: Ahnfelt-Rønne I. Pinacidil. Preclinical investigations. Drugs. 1988;36 Suppl 7:4-9. Review. PubMed PMID: 3076134.
3: Cohen ML, Kurz KD. Pinacidil-induced vascular relaxation: comparison to other vasodilators and to classical mechanisms of vasodilation. J Cardiovasc Pharmacol. 1988;12 Suppl 2:S5-9. PubMed PMID: 2466179.
4: Zushida K, Onodera K, Kamei J. Effect of diabetes on pinacidil-induced antinociception in mice. Eur J Pharmacol. 2002 Oct 25;453(2-3):209-15. PubMed PMID: 12398906.
5: Nakashima M, Li Y, Seki N, Kuriyama H. Pinacidil inhibits neuromuscular transmission indirectly in the guinea-pig and rabbit mesenteric arteries. Br J Pharmacol. 1990 Nov;101(3):581-6. PubMed PMID: 1963799; PubMed Central PMCID: PMC1917751.
6: Gollasch M, Bychkov R, Ried C, Behrendt F, Scholze S, Luft FC, Haller H. Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells. J Pharmacol Exp Ther. 1995 Nov;275(2):681-92. PubMed PMID: 7473155.
7: Levin RM, Hayes L, Zhao Y, Wein AJ. Effect of pinacidil on spontaneous and evoked contractile activity. Pharmacology. 1992;45(1):1-8. PubMed PMID: 1354875.
8: Gribble FM, Reimann F, Ashfield R, Ashcroft FM. Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A. Mol Pharmacol. 2000 Jun;57(6):1256-61. PubMed PMID: 10825398.
9: Choi EM, Jung WW, Suh KS. Pinacidil protects osteoblastic cells against antimycin A-induced oxidative damage. Mol Med Rep. 2015 Jan;11(1):746-52. doi: 10.3892/mmr.2014.2721. Epub 2014 Oct 21. PubMed PMID: 25334089.
10: Goldberg MR, Rockhold FW, Thompson WL, DeSante KA. Clinical pharmacokinetics of pinacidil, a potassium channel opener, in hypertension. J Clin Pharmacol. 1989 Jan;29(1):33-40. PubMed PMID: 2708546.
