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MedKoo Cat#: 328301 | Name: Tolfenamic acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tolfenamic acid, also known as Clotam, is a non-steroidal anti-inflammatory agent. Tolfenamic acid interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. Tolfenamic acid has been shown to exhibit anti-cancer activities in several types of cancer.

Chemical Structure

Tolfenamic acid
CAS#13710-19-5

Theoretical Analysis

MedKoo Cat#: 328301

Name: Tolfenamic acid

CAS#: 13710-19-5

Chemical Formula: C14H12ClNO2

Exact Mass: 261.0557

Molecular Weight: 261.71

Elemental Analysis: C, 64.25; H, 4.62; Cl, 13.55; N, 5.35; O, 12.23

Price and Availability

Size Price Availability Quantity
5g USD 250.00
10g USD 450.00
20g USD 850.00
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Related CAS #
No Data
Synonym
Tolfenamic acid; Clotam;
IUPAC/Chemical Name
2-((3-chloro-2-methylphenyl)amino)benzoic acid
InChi Key
YEZNLOUZAIOMLT-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)
SMILES Code
O=C(O)C1=CC=CC=C1NC2=CC=CC(Cl)=C2C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 261.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ha T, Lou Z, Baek SJ, Lee SH. Tolfenamic acid downregulates β-catenin in colon cancer. Int Immunopharmacol. 2016 Jun;35:287-93. doi: 10.1016/j.intimp.2016.04.008. Epub 2016 Apr 16. PubMed PMID: 27089389. 2: Adwan L, Subaiea GM, Basha R, Zawia NH. Tolfenamic acid reduces tau and CDK5 levels: implications for dementia and tauopathies. J Neurochem. 2015 Apr;133(2):266-72. doi: 10.1111/jnc.12960. Epub 2014 Oct 18. PubMed PMID: 25279694; PubMed Central PMCID: PMC4385008. 3: Subaiea GM, Ahmed AH, Adwan LI, Zawia NH. Reduction of amyloid-β deposition and attenuation of memory deficits by tolfenamic acid. J Alzheimers Dis. 2015;43(2):425-33. doi: 10.3233/JAD-132726. PubMed PMID: 25096618. 4: Schlapp G, Goyeneche L, Fernández G, Menchaca A, Crispo M. Administration of the nonsteroidal anti-inflammatory drug tolfenamic acid at embryo transfer improves maintenance of pregnancy and embryo survival in recipient mice. J Assist Reprod Genet. 2015 Feb;32(2):271-5. doi: 10.1007/s10815-014-0378-x. Epub 2015 Jan 6. PubMed PMID: 25561155; PubMed Central PMCID: PMC4354194. 5: Tarushi A, Perontsis S, Hatzidimitriou AG, Papadopoulos AN, Kessissoglou DP, Psomas G. Copper(II) complexes with the non-steroidal anti-inflammatory drug tolfenamic acid: Structure and biological features. J Inorg Biochem. 2015 Aug;149:68-79. doi: 10.1016/j.jinorgbio.2015.02.019. Epub 2015 Mar 6. PubMed PMID: 25824465. 6: Adwan L, Subaiea GM, Zawia NH. Tolfenamic acid downregulates BACE1 and protects against lead-induced upregulation of Alzheimer's disease related biomarkers. Neuropharmacology. 2014 Apr;79:596-602. doi: 10.1016/j.neuropharm.2014.01.009. Epub 2014 Jan 21. PubMed PMID: 24462621. 7: Shelake S, Eslin D, Sutphin RM, Sankpal UT, Wadwani A, Kenyon LE, Tabor-Simecka L, Bowman WP, Vishwanatha JK, Basha R. Combination of 13 cis-retinoic acid and tolfenamic acid induces apoptosis and effectively inhibits high-risk neuroblastoma cell proliferation. Int J Dev Neurosci. 2015 Nov;46:92-9. doi: 10.1016/j.ijdevneu.2015.07.012. Epub 2015 Aug 10. PubMed PMID: 26287661. 8: Zhang X, Lee SH, Min KW, McEntee MF, Jeong JB, Li Q, Baek SJ. The involvement of endoplasmic reticulum stress in the suppression of colorectal tumorigenesis by tolfenamic acid. Cancer Prev Res (Phila). 2013 Dec;6(12):1337-47. doi: 10.1158/1940-6207.CAPR-13-0220. Epub 2013 Oct 8. PubMed PMID: 24104354; PubMed Central PMCID: PMC3855893. 9: de Melo da Silva L, Pereira Cavalcante R, Fabbro Cunha R, Gozzi F, Falcao Dantas R, de Oliveira SC, Machulek A Junior. Tolfenamic acid degradation by direct photolysis and the UV-ABC/H(2)O(2) process: factorial design, kinetics, identification of intermediates, and toxicity evaluation. Sci Total Environ. 2016 Aug 27;573:518-531. doi: 10.1016/j.scitotenv.2016.08.139. [Epub ahead of print] PubMed PMID: 27575359. 10: Nicpoń J, Siudzińska A, Marędziak M, Śmieszek A, Basińska K, Koszykowska M. The effect of metamizole and tolfenamic acid on canine and equine adipose-derived mesenchymal stem cells (ASCs) an in vitro research. Pol J Vet Sci. 2015;18(1):3-11. PubMed PMID: 25928904.

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