MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 526862 | Name: SKF-96067

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SKF-96067, also known as SK&F-96067, is a reversible, lumenally acting inhibitor of the gastric (H+ + K+)-ATPase. At pH 7.0, SK&F 96067 inhibited K(+)-stimulated ATPase activity competitively with respect to the activating cation K+, with a Ki value of 0.39 +/- 0.05 microM. Under comparable conditions, SK&F 96067 was 32 times more potent as an inhibitor of the gastric (H+ + K+)-ATPase relative to the closely related (Na+ + K+)-ATPase.

Chemical Structure

SKF-96067
SKF-96067
CAS#115607-61-9

Theoretical Analysis

MedKoo Cat#: 526862

Name: SKF-96067

CAS#: 115607-61-9

Chemical Formula: C21H22N2O2

Exact Mass: 334.1681

Molecular Weight: 334.42

Elemental Analysis: C, 75.42; H, 6.63; N, 8.38; O, 9.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
SKF-96067; SKF 96067; SKF96067; SK&F-96067; SK&F 96067; SK&F96067.
IUPAC/Chemical Name
3-butyryl-4-(2-methylphenylamino)-8-methoxyquinoline
InChi Key
MAVJDLHBPIXVJL-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H22N2O2/c1-4-8-18(24)16-13-22-21-15(10-7-12-19(21)25-3)20(16)23-17-11-6-5-9-14(17)2/h5-7,9-13H,4,8H2,1-3H3,(H,22,23)
SMILES Code
COC1=C2N=CC(C(CCC)=O)=C(NC3=CC=CC=C3C)C2=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 334.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rhoden KJ, Tallini G, Douglas JS. H+-K+ ATPase inhibitors cause relaxation of guinea pig and human airway smooth muscle in vitro. J Pharmacol Exp Ther. 1996 Mar;276(3):897-903. PubMed PMID: 8786567. 2: Parsons ME, Rushant B, Rasmussen TC, Leach C, Ife RJ, Postius S, Pope AJ. Properties of the reversible, K(+)-competitive inhibitor of the gastric (H+/K+)-ATPase, SK&F 97574. II. Pharmacological properties. Biochem Pharmacol. 1995 Nov 9;50(10):1551-6. PubMed PMID: 7503756. 3: Sarges R, Gallagher A, Chambers TJ, Yeh LA. Inhibition of bone resorption by H+/K(+)-ATPase inhibitors. J Med Chem. 1993 Sep 17;36(19):2828-30. PubMed PMID: 8410997. 4: Moore TD, Metcalf AC, Swagzdis JE, Doyle E. High-performance liquid chromatographic determination of concentrations of the reversible H+/K+ ATPase inhibitor SK&F 97574 in plasma. J Chromatogr. 1993 Sep 8;619(1):172-6. PubMed PMID: 8245159. 5: Pope AJ, Parsons ME. Reversible inhibitors of the gastric H+/K(+)-transporting ATPase: a new class of anti-secretory agent. Trends Pharmacol Sci. 1993 Sep;14(9):323-5. Review. PubMed PMID: 8249153. 6: Keeling DJ, Malcolm RC, Laing SM, Ife RJ, Leach CA. SK&F 96067 is a reversible, lumenally acting inhibitor of the gastric (H+ + K+)-ATPase. Biochem Pharmacol. 1991 Jun 21;42(1):123-30. PubMed PMID: 1648919.

View History

Phenyl-glutarimide 4'-oxyacetic acid

Phenyl-glutarimide 4'-oxyacetic acid

Featured