MedKoo Cat#: 326881 | Name: Beloxepin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Beloxepin, also known as ADL-6906; ORG-4428, is an oral dual selective serotonin and norepinephrine uptake inhibitor.

Chemical Structure

Beloxepin
Beloxepin
CAS#135928-30-2

Theoretical Analysis

MedKoo Cat#: 326881

Name: Beloxepin

CAS#: 135928-30-2

Chemical Formula: C19H21NO2

Exact Mass: 295.1572

Molecular Weight: 295.38

Elemental Analysis: C, 77.26; H, 7.17; N, 4.74; O, 10.83

Price and Availability

Size Price Availability Quantity
1mg USD 190.00 Ready to ship
5mg USD 750.00 Ready to ship
10mg USD 1,250.00 Ready to ship
25mg USD 2,250.00 Ready to ship
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Related CAS #
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Synonym
ADL-6906; ADL 6906; ADL6906; ORG-4428; ORG4428; ORG 4428; Beloxepin.
IUPAC/Chemical Name
cis-1,3,4,13b-Tetrahydro-2,10-dimethyldibenz(2,3:6,7)oxepino(4,5-c)pyridin-4a(2H)-ol
InChi Key
RPMDQAYGQBREBS-VQIMIIECSA-N
InChi Code
InChI=1S/C19H21NO2/c1-13-6-5-7-14-16-12-20(2)11-10-19(16,21)15-8-3-4-9-17(15)22-18(13)14/h3-9,16,21H,10-12H2,1-2H3/t16-,19-/m1/s1
SMILES Code
O[C@]12[C@](C3=CC=CC(C)=C3OC4=CC=CC=C42)([H])CN(C)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
Beloxepin, also known as ADL-6906; ORG-4428, is an oral dual selective serotonin and norepinephrine uptake inhibitor.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 295.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Fujimaki K, Morinobu S, Duman RS. Administration of a cAMP phosphodiesterase 4 inhibitor enhances antidepressant-induction of BDNF mRNA in rat hippocampus. Neuropsychopharmacology. 2000 Jan;22(1):42-51. doi: 10.1016/S0893-133X(99)00084-6. PMID: 10633490. 2: van Bemmel AL, Vermeeren MT, Ruigt G, Sennef C. The acute effects of the noradrenaline reuptake inhibitor Org 4428 on EEG sleep in healthy volunteers. Neuropsychobiology. 1999;40(2):107-14. doi: 10.1159/000026605. PMID: 10474065. 3: Paanakker JE, de Jong J, Thio JM, van Hal HJ. Validation of an LC-MS assay for the quantification of the enantiomers of Org 4428 in human plasma. J Pharm Biomed Anal. 1998 Feb;16(6):981-9. doi: 10.1016/s0731-7085(97)00113-1. PMID: 9547701. 4: Inoue T, Hashimoto S, Tsuchiya K, Izumi T, Ohmori T, Koyama T. Effect of citalopram, a selective serotonin reuptake inhibitor, on the acquisition of conditioned freezing. Eur J Pharmacol. 1996 Sep 5;311(1):1-6. doi: 10.1016/0014-2999(96)00391-3. PMID: 8884229.