Synonym
FF-106; FF 106; FF106; Butibufen
IUPAC/Chemical Name
2-(p-Isobutylphenyl)butyric acid
InChi Key
UULSXYSSHHRCQK-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H20O2/c1-4-13(14(15)16)12-7-5-11(6-8-12)9-10(2)3/h5-8,10,13H,4,9H2,1-3H3,(H,15,16)
SMILES Code
CCC(C1=CC=C(CC(C)C)C=C1)C(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS#
CAS No.
55837-18-8 (Butibufen )
60682-24-8 (Butibufen Sodium)
Preparing Stock Solutions
The following data is based on the
product
molecular weight
220.31
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Castell JV, Gómez-Lechón MJ, Miranda MA, Morera IM. Phototoxicity of non- steroidal anti-inflammatory drugs: in vitro testing of the photoproducts of Butibufen and Flurbiprofen. J Photochem Photobiol B. 1992 Apr 15;13(1):71-81. doi: 10.1016/1011-1344(92)80041-s. PMID: 1403370.
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6: Aparicio L. Some aspects of the pharmacology of butibufen, a non-steroidal anti-inflammatory agent. Arch Int Pharmacodyn Ther. 1977 May;227(1):130-41. PMID: 901061.
7: Alamo C, Ferrándiz B, López-Muñoz F, Alguacil LF. Influence of butibufen on enzyme activity and lysosomal stabilization ex vivo: a comparative study with hydrocortisone and acetylsalicylic acid. Methods Find Exp Clin Pharmacol. 1995 Jun;17(5):303-10. PMID: 8830198.
8: González Tavares L, Pérez de la Cruz MJ, Sanz Saiz P, Camacho MA, Martin JL. High pressure liquid chromatographic determination of the new non-steroidal anti-inflammatory agent butibufen. Arzneimittelforschung. 1992 Jun;42(6):818-20. PMID: 1418037.
9: Kerdesky FA, Brooks CD, Hulkower KI, Bouska JB, Bell RL. Conversion of cyclooxygenase inhibitors into hydroxythiazole 5-lipoxygenase inhibitors. Bioorg Med Chem. 1997 Feb;5(2):393-6. doi: 10.1016/s0968-0896(96)00255-6. PMID: 9061203.
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11: Miranda MA, Morera I, Vargas F, Gómez-Lechón MJ, Castell JV. In vitro assessment of the phototoxicity of anti-inflammatory 2-arylpropionic acids. Toxicol In Vitro. 1991;5(5-6):451-5. doi: 10.1016/0887-2333(91)90071-k. PMID: 20732055.
12: Rico H, Alamo C, Revilla M, Villa LF, Alguacil LF. Effect of adjuvant- induced arthritis on bone mass in rats and its prevention by non-steroid anti- inflammatory drugs (NSAIDs). Clin Exp Rheumatol. 1992 Nov-Dec;10(6):595-7. PMID: 1483311.
