MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 525977 | Name: PF-9404C

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-9404C is the S-S diesteroisomer of a novel blocker of beta adrenergic receptors with vasodilatory properties. In rat aorta smooth muscle cells, PF9404C increased the formation of cyclic GMP from 3 pmol mg−1 protein in basal conditions, to 53 pmol mg−1 protein in 10 μM.

Chemical Structure

PF-9404C
PF-9404C
CAS#780825-97-0

Theoretical Analysis

MedKoo Cat#: 525977

Name: PF-9404C

CAS#: 780825-97-0

Chemical Formula: C16H25N3O9

Exact Mass: 403.1591

Molecular Weight: 403.39

Elemental Analysis: C, 47.64; H, 6.25; N, 10.42; O, 35.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
PF-9404C; PF 9404C; PF9404C.
IUPAC/Chemical Name
1,2-Propanediol, 3-((4-((2S)-2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)methoxy)-, 1,2-dinitrate, (2S)-
InChi Key
FIAGQHFOTZHMQM-GOEBONIOSA-N
InChi Code
InChI=1S/C16H25N3O9/c1-12(2)17-7-14(20)9-26-15-5-3-13(4-6-15)8-25-10-16(28-19(23)24)11-27-18(21)22/h3-6,12,14,16-17,20H,7-11H2,1-2H3/t14-,16+/m0/s1
SMILES Code
CC(NC[C@H](O)COC1=CC=C(COC[C@@H](O[N+]([O-])=O)CO[N+]([O-])=O)C=C1)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 403.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Villarroya M, López MG, de Pascual R, García AG. Preclinical profile of PF9404C, a nitric oxide donor with beta receptor blocking properties. Cardiovasc Drug Rev. 2005 Summer;23(2):149-60. Review. PubMed PMID: 16007231. 2: Ruiz-Nuño A, Rosado A, García AG, López MG, Villarroya M. Differences in the vascular selectivity and tolerance between the NO donor/beta-blocker PF9404C and nitroglycerin. Eur J Pharmacol. 2004 Sep 13;498(1-3):203-10. PubMed PMID: 15363996. 3: Villarroya M, Herrero CJ, Ruíz-Nuño A, de Pascual R, del Valle M, Michelena P, Grau M, Carrasco E, López MG, García AG. PF9404C, a new slow NO donor with beta receptor blocking properties. Br J Pharmacol. 1999 Dec;128(8):1713-22. PubMed PMID: 10588927; PubMed Central PMCID: PMC1571821.