Rogaratinib, also known as BAY-1163877, is an aberrant fibroblast growth factor receptor (FGFR) inhibitor. Rogaratinib is as an orally available, selective and potent inhibitor of FGFR-1, -2 and -3 kinase activity. FGFRs are a family of receptor tyrosine kinases, which may be upregulated in various tumor cell types and may be involved in tumor cell differentiation and proliferation, tumor angiogenesis, and tumor cell survival.
MedKoo Cat#: 327022
Name: Rogaratinib
CAS#: 1443530-05-9
Chemical Formula: C23H26N6O3S
Exact Mass: 466.1787
Molecular Weight: 466.56
Elemental Analysis: C, 59.21; H, 5.62; N, 18.01; O, 10.29; S, 6.87
Solvent | mg/mL | mM | |
---|---|---|---|
Solubility | |||
DMSO | 5.0 | 10.72 |
The following data is based on the product molecular weight 466.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |