MedKoo Cat#: 525927 | Name: PF-02575799

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-02575799 is a microsomal triglyceride transfer protein (MTP) inhibitor with potential for decreased active metabolite load. It can reduce the potential for unwanted liver MTP inhibition and associated side-effects.

Chemical Structure

PF-02575799
CAS#863491-70-7

Theoretical Analysis

MedKoo Cat#: 525927

Name: PF-02575799

CAS#: 863491-70-7

Chemical Formula: C42H37FN4O4

Exact Mass: 680.2799

Molecular Weight: 680.78

Elemental Analysis: C, 74.10; H, 5.48; F, 2.79; N, 8.23; O, 9.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PF-02575799; PF 02575799; PF02575799.
IUPAC/Chemical Name
(S)-N-(2-((4-fluorobenzyl)(methyl)amino)-2-oxo-1-phenylethyl)-2-(4'-isopropoxy-[1,1'-biphenyl]-2-carboxamido)quinoline-6-carboxamide
InChi Key
HMTLPJFACYNTHS-KDXMTYKHSA-N
InChi Code
InChI=1S/C42H37FN4O4/c1-27(2)51-34-21-15-29(16-22-34)35-11-7-8-12-36(35)41(49)45-38-24-18-31-25-32(17-23-37(31)44-38)40(48)46-39(30-9-5-4-6-10-30)42(50)47(3)26-28-13-19-33(43)20-14-28/h4-25,27,39H,26H2,1-3H3,(H,46,48)(H,44,45,49)/t39-/m0/s1
SMILES Code
CC(C)Oc1ccc(cc1)c2ccccc2C(=O)Nc3ccc4cc(ccc4n3)C(=O)N[C@@H](c5ccccc5)C(=O)N(C)Cc6ccc(cc6)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 680.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Robinson RP, Bartlett JA, Bertinato P, Bessire AJ, Cosgrove J, Foley PM, Manion TB, Minich ML, Ramos B, Reese MR, Schmahai TJ, Swick AG, Tess DA, Vaz A, Wolford A. Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4150-4. doi: 10.1016/j.bmcl.2011.05.099. Epub 2011 Jun 2. PubMed PMID: 21684740.