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MedKoo Cat#: 525924 | Name: PF-02367982

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-02367982 is a novel, potent, and selective nonsteroidal progesterone antagonist.

Chemical Structure

PF-02367982
CAS#913344-84-0

Theoretical Analysis

MedKoo Cat#: 525924

Name: PF-02367982

CAS#: 913344-84-0

Chemical Formula: C19H20N4O2

Exact Mass: 336.1586

Molecular Weight: 336.40

Elemental Analysis: C, 67.84; H, 5.99; N, 16.66; O, 9.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PF-02367982; PF 02367982; PF02367982.
IUPAC/Chemical Name
1H-Pyrazole-1-acetamide, 4-(4-cyanophenoxy)-3,5-dicyclopropyl-N-methyl-
InChi Key
PQGLAOODCQDRAR-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H20N4O2/c1-21-16(24)11-23-18(14-6-7-14)19(17(22-23)13-4-5-13)25-15-8-2-12(10-20)3-9-15/h2-3,8-9,13-14H,4-7,11H2,1H3,(H,21,24)
SMILES Code
O=C(NC)CN1N=C(C2CC2)C(OC3=CC=C(C#N)C=C3)=C1C4CC4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 336.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Schmidt C, Klammt J, Thome UH, Laube M. The interaction of glucocorticoids and progesterone distinctively affects epithelial sodium transport. Lung. 2014 Dec;192(6):935-46. doi: 10.1007/s00408-014-9640-3. Epub 2014 Aug 31. PubMed PMID: 25173779. 2: de Giorgio-Miller A, Bungay P, Tutt M, Owen J, Goodwin D, Pullen N. The translational pharmacology of a novel, potent, and selective nonsteroidal progesterone receptor antagonist, 2-[4-(4-cyano-phenoxy)-3,5-dicyclopropyl-1H-pyrazol-1-yl]-N-methylacetamide (PF-02367982). J Pharmacol Exp Ther. 2008 Oct;327(1):78-87. doi: 10.1124/jpet.108.140467. Epub 2008 Jul 1. PubMed PMID: 18593954.