PF-00489791 | PF-4634817 | CAS#853003-48-2 | PDE-5 Inhibitor

MedKoo Cat#: 525921 | Name: PF-00489791

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-00489791, also known as PF-4634817, is an inhibitor of phosphodiesterase type 5. PF-00489791 will enhance the relaxation of blood vessels within the kidney and so reduce blood pressure, improving renal function.

Chemical Structure

PF-00489791

CAS#853003-48-2

Theoretical Analysis

MedKoo Cat#: 525921

Name: PF-00489791

CAS#: 853003-48-2

Chemical Formula: C20H28N8O4S

Exact Mass: 476.1954

Molecular Weight: 476.56

Elemental Analysis: C, 50.41; H, 5.92; N, 23.51; O, 13.43; S, 6.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

PF-00489791; PF 00489791; PF00489791; PF-4634817; PF 4634817; PF4634817.

IUPAC/Chemical Name

1H-Pyrazolo(4,3-d)pyrimidine-3-carboxamide, 1-(2-ethoxyethyl)-5-(ethylmethylamino)-7-((4-methyl-2-pyridinyl)amino)-N-(methylsulfonyl)

InChi Key

ZUHZNKJIJDAJFD-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H28N8O4S/c1-6-27(4)20-23-15-16(19(29)26-33(5,30)31)25-28(10-11-32-7-2)17(15)18(24-20)22-14-12-13(3)8-9-21-14/h8-9,12H,6-7,10-11H2,1-5H3,(H,26,29)(H,21,22,23,24)

SMILES Code

O=C(C1=NN(CCOCC)C2=C(NC3=NC=CC(C)=C3)N=C(N(CC)C)N=C21)NS(=O)(C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 476.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Scheele W, Diamond S, Gale J, Clerin V, Tamimi N, Le V, Walley R, Grover-Páez F, Perros-Huguet C, Rolph T, El Nahas M. Phosphodiesterase Type 5 Inhibition Reduces Albuminuria in Subjects with Overt Diabetic Nephropathy. J Am Soc Nephrol. 2016 Apr 25. pii: ASN.2015050473. [Epub ahead of print] PubMed PMID: 27113485. 2: Afsar B, Ortiz A, Covic A, Gaipov A, Esen T, Goldsmith D, Kanbay M. Phosphodiesterase type 5 inhibitors and kidney disease. Int Urol Nephrol. 2015 Sep;47(9):1521-8. doi: 10.1007/s11255-015-1071-4. Epub 2015 Aug 5. Review. PubMed PMID: 26242375. 3: Wolk R, Smith WB, Neutel JM, Rubino J, Xuan D, Mancuso J, Gilbert J, Pressler ML. Blood pressure lowering effects of a new long-acting inhibitor of phosphodiesterase 5 in patients with mild to moderate hypertension. Hypertension. 2009 Jun;53(6):1091-7. doi: 10.1161/HYPERTENSIONAHA.109.132225. Epub 2009 Apr 27. PubMed PMID: 19398651.