Morponidazole | CAS#92478-27-8 | Nitroimidazole antibiotic

MedKoo Cat#: 326848 | Name: Morponidazole

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Morponidazole was approved by China Food and Drug Administration (CFDA) on February 24, 2014. Morponidazole is a nitroimidazoles antibiotic used to treat bacterial infections including appendicitis and pelvic inflammatory disease. Morponidazole is a nitroimidazoles antibiotic indicated for the treatment of bacterial infections including appendicitis and pelvic inflammatory disease (PID) caused by anaerobic bacteria.

Chemical Structure

Morponidazole

CAS#92478-27-8

Theoretical Analysis

MedKoo Cat#: 326848

Name: Morponidazole

CAS#: 92478-27-8

Chemical Formula: C11H18N4O4

Exact Mass: 270.1328

Molecular Weight: 270.29

Elemental Analysis: C, 48.88; H, 6.71; N, 20.73; O, 23.68

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 750.00	2 Weeks
10mg	USD 1,250.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

Morponidazole; Morponidazol; Morponidazolum; Morinidazole, trade name: Lingda®;

IUPAC/Chemical Name

1-(2-methyl-5-nitro-1H-imidazol-1-yl)-3-morpholinopropan-2-ol

InChi Key

GAZGHCHCYRSPIV-UHFFFAOYSA-N

InChi Code

InChI=1S/C11H18N4O4/c1-9-12-6-11(15(17)18)14(9)8-10(16)7-13-2-4-19-5-3-13/h6,10,16H,2-5,7-8H2,1H3

SMILES Code

O=[N+](C1=CN=C(C)N1CC(O)CN2CCOCC2)[O-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Morponidazole is a nitroimidazoles antibiotic.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	100.0	369.97

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 270.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1: Pang X, Zhang Y, Gao R, Zhong K, Zhong D, Chen X. Effects of rifampin and ketoconazole on pharmacokinetics of morinidazole in healthy chinese subjects. Antimicrob Agents Chemother. 2014 Oct;58(10):5987-93. doi: 10.1128/AAC.03382-14. Epub 2014 Jul 28. PubMed PMID: 25070100; PubMed Central PMCID: PMC4187946. 2: Zhong K, Gao Z, Li Q, Zhong D, Chen X. A chiral high-performance liquid chromatography-tandem mass spectrometry method for the stereospecific determination of morinidazole in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jun 15;961:49-55. doi: 10.1016/j.jchromb.2014.04.049. Epub 2014 May 2. PubMed PMID: 24858695. 3: Zhong K, Li X, Xie C, Zhang Y, Zhong D, Chen X. Effects of renal impairment on the pharmacokinetics of morinidazole: uptake transporter-mediated renal clearance of the conjugated metabolites. Antimicrob Agents Chemother. 2014 Jul;58(7):4153-61. doi: 10.1128/AAC.02414-14. Epub 2014 May 12. PubMed PMID: 24820074; PubMed Central PMCID: PMC4068547. 4: Zhang H, Huang L, Huang YY, Yi B, Pei Q, Tan HY, Huang J, Liu JS, Yuan H, Yang GP. Pharmacokinetics of single-dose morinidazole in patients with severe renal impairment. Int J Clin Pharmacol Ther. 2014 Feb;52(2):159-65. doi: 10.5414/CP202000. PubMed PMID: 24290410. 5: Jiang Y, Wu X, Lingling E. Comment on "Simultaneous quantification of metronidazole, tinidazole, ornidazole and morinidazole in human saliva": Saliva or gingival crevicular fluid? J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jan 15;913-914:169-70. doi: 10.1016/j.jchromb.2012.11.022. Epub 2012 Dec 13. PubMed PMID: 23314355. 6: Tan H, Yang G, Yu P, Huang Y, Pei Q, Yuan H, Huang Z, Xie F, Mu L. Simultaneous determination of morinidazole and its carbonylation metabolite in human plasma: application to a pharmacokinetic study involving renal insufficiency patients and healthy volunteers. J Pharm Biomed Anal. 2013 Mar 25;76:75-80. doi: 10.1016/j.jpba.2012.11.037. Epub 2012 Dec 13. PubMed PMID: 23298909. 7: Gao R, Zhong D, Liu K, Xia Y, Shi R, Li H, Chen X. Simultaneous determination of morinidazole, its N-oxide, sulfate, and diastereoisomeric N(+)-glucuronides in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Nov 1;908:52-8. doi: 10.1016/j.jchromb.2012.09.017. Epub 2012 Sep 25. PubMed PMID: 23122401. 8: Wang Y, Zhang P, Jiang N, Gong X, Meng L, Wang D, Ou N, Zhang H. Simultaneous quantification of metronidazole, tinidazole, ornidazole and morinidazole in human saliva. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 15;899:27-30. doi: 10.1016/j.jchromb.2012.04.032. Epub 2012 May 15. PubMed PMID: 22658465. 9: Jin S, Zhang YF, Chen XY, Liu K, Zhong DF. [Enantioselective determinination of R-warfarin/S-warfarin in human plasma using liquid chromatography-tandem mass spectrometry and its application in a drug-drug interaction study]. Yao Xue Xue Bao. 2012 Jan;47(1):105-9. Chinese. PubMed PMID: 22493814. 10: Gao R, Li L, Xie C, Diao X, Zhong D, Chen X. Metabolism and pharmacokinetics of morinidazole in humans: identification of diastereoisomeric morpholine N+-glucuronides catalyzed by UDP glucuronosyltransferase 1A9. Drug Metab Dispos. 2012 Mar;40(3):556-67. doi: 10.1124/dmd.111.042689. Epub 2011 Dec 19. PubMed PMID: 22184458. 11: Lv W. Investigation of the effects of 24 bio-matrices on the LC-MS/MS analysis of morinidazole. Talanta. 2010 Jan 15;80(3):1406-12. doi: 10.1016/j.talanta.2009.09.043. Epub . PubMed PMID: 20006106.