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MedKoo Cat#: 525916 | Name: PF 00277343

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF 00277343 is a thyroid receptor agonist that is used for the treatment of androgenetic alopecia.

Chemical Structure

PF 00277343
CAS#332926-04-2

Theoretical Analysis

MedKoo Cat#: 525916

Name: PF 00277343

CAS#: 332926-04-2

Chemical Formula: C24H20FN3O4

Exact Mass: 433.1430

Molecular Weight: 433.44

Elemental Analysis: C, 66.51; H, 4.65; F, 4.38; N, 9.69; O, 14.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PF 00277343; PF-00277343; PF00277343.
IUPAC/Chemical Name
1,2,4-Triazine-3,5(2H,4H)-dione, 2-(4-(3-((4-fluorophenyl)methyl)-4-hydroxyphenoxy)-3,5-dimethylphenyl)-
InChi Key
HQXKNHQWCAXRDN-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H20FN3O4/c1-14-9-19(28-24(31)27-22(30)13-26-28)10-15(2)23(14)32-20-7-8-21(29)17(12-20)11-16-3-5-18(25)6-4-16/h3-10,12-13,29H,11H2,1-2H3,(H,27,30,31)
SMILES Code
O=C(N1)N(C2=CC(C)=C(OC3=CC=C(O)C(CC4=CC=C(F)C=C4)=C3)C(C)=C2)N=CC1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 433.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li JJ, Mitchell LH, Dow RL. Thyroid receptor agonists for the treatment of androgenetic alopecia. Bioorg Med Chem Lett. 2010 Jan 1;20(1):306-8. doi: 10.1016/j.bmcl.2009.10.109. Epub 2009 Oct 29. PubMed PMID: 19900809.