KM-10103 | KM10103 | CAS# 883023-03-8 | β-cell protector

MedKoo Cat#: 526837 | Name: KM10103

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KM10103 is a potent β-cell protector. KM10103 exhibits β-cell-protective activities against ER stress. Endoplasmic reticulum (ER) stress plays an important role in the decline in pancreatic β cell function and mass observed in type 2 diabetes.

Chemical Structure

KM10103

CAS# 883023-03-8

Theoretical Analysis

MedKoo Cat#: 526837

Name: KM10103

CAS#: 883023-03-8

Chemical Formula: C19H26N2OS

Exact Mass: 330.1766

Molecular Weight: 330.49

Elemental Analysis: C, 69.05; H, 7.93; N, 8.48; O, 4.84; S, 9.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

KM-10103; KM 10103; KM10103.

IUPAC/Chemical Name

1-((3s,5s,7s)-adamantan-1-yl)-3-(2-(methylthio)benzyl)urea

InChi Key

WPXRUUMUUGRZGQ-MYUHZXPASA-N

InChi Code

InChI=1S/C19H26N2OS/c1-23-17-5-3-2-4-16(17)12-20-18(22)21-19-9-13-6-14(10-19)8-15(7-13)11-19/h2-5,13-15H,6-12H2,1H3,(H2,20,21,22)/t13-,14+,15-,19?

SMILES Code

O=C(NCC1=CC=CC=C1SC)NC23C[C@H]4C[C@@H](C3)C[C@H](C4)C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Pancreatic insulin-producing β-cell dysfunction and death plays central roles in the onset and progression of both type 1 and type 2 diabetes. Current antidiabetic drugs cannot halt the ongoing progression of β-cell dysfunction and death. In diabetes, a major cause for the decline in β-cell function and survival is endoplasmic reticulum (ER) stress.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 330.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Tran, K.; Li, Y.; Duan, H.; Arora, D.; Lim, H. Y.; Wang, W. Identification of Small Molecules That Protect Pancreatic Beta Cells against Endoplasmic Reticulum Stress-Induced Cell Death. ACS Chem. Biol. 2014, 9, 2796−2806.