LY 235959 | CAS#137433-06-8 | NMDA receptor antagonist

MedKoo Cat#: 525525 | Name: LY 235959

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY 235959 is a competitive NMDA receptor antagonist.

Chemical Structure

LY 235959

CAS#137433-06-8

Theoretical Analysis

MedKoo Cat#: 525525

Name: LY 235959

CAS#: 137433-06-8

Chemical Formula: C11H20NO5P

Exact Mass: 277.1079

Molecular Weight: 277.26

Elemental Analysis: C, 47.65; H, 7.27; N, 5.05; O, 28.85; P, 11.17

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 310.00
50mg	USD 920.00

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Related CAS #

No Data

Synonym

LY 235959; LY235959; LY-235959.

IUPAC/Chemical Name

3-Isoquinolinecarboxylic acid, decahydro-6-(phosphonomethyl)-, (3S-(3alpha,4aalpha,6beta,8aalpha))-

InChi Key

STIRHCNEGQQBOY-QEYWKRMJSA-N

InChi Code

InChI=1S/C11H20NO5P/c13-11(14)10-4-9-3-7(6-18(15,16)17)1-2-8(9)5-12-10/h7-10,12H,1-6H2,(H,13,14)(H2,15,16,17)/t7-,8-,9+,10-/m0/s1

SMILES Code

O=C([C@H]1NC[C@]2([H])CC[C@H](CP(O)(O)=O)C[C@]2([H])C1)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 277.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Rawls SM, Gomez T, Raffa RB. An NMDA antagonist (LY 235959) attenuates abstinence-induced withdrawal of planarians following acute exposure to a cannabinoid agonist (WIN 55212-2). Pharmacol Biochem Behav. 2007 Mar;86(3):499-504. Epub 2007 Jan 20. PubMed PMID: 17306870. 2: Gasior M, Borowicz K, Kleinrok Z, Starownik R, Czuczwar SJ. Anticonvulsant and adverse effects of MK-801, LY 235959, and GYKI 52466 in combination with Ca2+ channel inhibitors in mice. Pharmacol Biochem Behav. 1997 Apr;56(4):629-35. PubMed PMID: 9130287. 3: Bhargava HN. Enhancement of morphine actions in morphine-naive and morphine-tolerant mice by LY 235959, a competitive antagonist of the NMDA receptor. Gen Pharmacol. 1997 Jan;28(1):61-4. PubMed PMID: 9112078. 4: Borowicz KK, Gasior M, Kleinrok Z, Czuczwar SJ. Competitive NMDA-receptor antagonists, LY 235959 and LY 233053, enhance the protective efficacy of various antiepileptic drugs against maximal electroshock-induced seizures in mice. Epilepsia. 1996 Jul;37(7):618-24. PubMed PMID: 8681893.