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MedKoo Cat#: 525524 | Name: LY 233536

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY 233536 is a novel competitive NMDA receptor antagonist.

Chemical Structure

LY 233536
LY 233536
CAS#136845-59-5

Theoretical Analysis

MedKoo Cat#: 525524

Name: LY 233536

CAS#: 136845-59-5

Chemical Formula: C12H19N5O2

Exact Mass: 265.1539

Molecular Weight: 265.32

Elemental Analysis: C, 54.32; H, 7.22; N, 26.40; O, 12.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LY 233536; LY-233536; LY233536.
IUPAC/Chemical Name
3-Isoquinolinecarboxylic acid, decahydro-6-(1H-tetrazol-5-ylmethyl)-, (3R-(3alpha,4aalpha,6beta,8aalpha))-
InChi Key
ACTONBBIVMTUAJ-DOLQZWNJSA-N
InChi Code
InChI=1S/C12H19N5O2/c18-12(19)10-5-9-3-7(1-2-8(9)6-13-10)4-11-14-16-17-15-11/h7-10,13H,1-6H2,(H,18,19)(H,14,15,16,17)/t7-,8-,9+,10-/m1/s1
SMILES Code
O=C([C@@H]1NC[C@@]2([H])CC[C@@H](CC3=NN=NN3)C[C@@]2([H])C1)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 265.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Geter-Douglass B, Witkin JM. Dizocilpine-like discriminative stimulus effects of competitive NMDA receptor antagonists in mice. Psychopharmacology (Berl). 1997 Sep;133(1):43-50. PubMed PMID: 9335079. 2: Buller AL, Monaghan DT. Pharmacological heterogeneity of NMDA receptors: characterization of NR1a/NR2D heteromers expressed in Xenopus oocytes. Eur J Pharmacol. 1997 Feb 5;320(1):87-94. PubMed PMID: 9049607. 3: Ginski MJ, Witkin JM. Sensitive and rapid behavioral differentiation of N-methyl-D-aspartate receptor antagonists. Psychopharmacology (Berl). 1994 May;114(4):573-82. PubMed PMID: 7855218. 4: Yoshiyama M, Roppolo JR, Thor KB, de Groat WC. Effects of LY274614, a competitive NMDA receptor antagonist, on the micturition reflex in the urethane-anaesthetized rat. Br J Pharmacol. 1993 Sep;110(1):77-86. PubMed PMID: 8106110; PubMed Central PMCID: PMC2175996. 5: Beaton JA, Stemsrud K, Monaghan DT. Identification of a novel N-methyl-D-aspartate receptor population in the rat medial thalamus. J Neurochem. 1992 Aug;59(2):754-7. PubMed PMID: 1385829.

View History

FPL-66564

FPL-66564